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Chapters
- 00:05Title
- 01:25Cell Culture
- 02:00Nude Rat Model of Bone Metastasis
- 04:10Magnetic Resonance Imaging (MRI)
- 05:09Volumetric Computed Tomography (VCT)
- 05:54Ultrasound (US)
- 07:06Postprocessing of Imaging Data
- 08:55Results: Multi-modal Imaging of Angiogenesis
- 11:57Conclusion
In the pathogenesis of bone metastasis, angiogenesis is a crucial process and therefore represents a target for imaging and therapy. Here, we present a rat model of site-specific breast cancer bone metastasis and describe strategies to non-invasively image angiogenesis in vivo using magnetic resonance imaging, volumetric computed tomography and ultrasound.
Tags
Multi-modal ImagingAngiogenesisNude Rat ModelBreast Cancer Bone MetastasisMagnetic Resonance ImagingVolumetric Computed TomographyUltrasoundExperimental Bone MetastasisIn Vivo AssessmentNon-invasive Imaging TechniquesMDA-MB-231 Human Breast Cancer CellsEpigastric Artery InjectionSite-specific Bone MetastasesDistal FemurProximal TibiaProximal FibulaMorphological Aspects Of AngiogenesisFunctional Aspects Of AngiogenesisDynamic Contrast-enhanced MRI (DCE-MRI)Regional Blood VolumePerfusionVessel Permeability
