Adolescent Female Rats
Adolescent Female Rats - Related Videos
03:20
Microinjection of Tetrodotoxin into the Brain of an Awake Female Rat to Inhibit Ovulation
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2025
Source: Silva, C. et al. Unraveling the Role of Discrete Areas of the Rat Brain in the Regulation of Ovulation through Reversible Inactivation by Tetrodotoxin Microinjections. J. Vis. Exp. (2020)This video demonstrates the protocol for microinjection of tetrodotoxin (TTX) into the hypothalamus of a freely moving rat to transiently inhibit neuronal activity, suppress gonadotropin-releasing hormone secretion, and prevent ovulation.
07:15
Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice
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Cited by 3 •
2024
We developed an accelerated social defeat stress model for adolescent C57BL/6 mice, which works in both males and females and allows exposure during discrete adolescent periods. Exposure to this model induces social avoidance, but only in a subset of defeated male and female mice.
06:15
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
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Cited by 17 •
2017
Here, we present a protocol that provoked cortisol reactivity in a vulnerable adolescent Mexican American sample utilizing a modified version of the Trier Social Stress Test (TSST). Saliva samples were collected at baseline, 15, 30, and 45 min post-TSST onset. Future research could utilize this modified TSST with vulnerable youth.
14:05
Adolescent Exam
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2025
Source: Heather Collette and Jaideep Talwalkar; Yale School of Medicine The adolescent module will focus on techniques to promote a trusting provider-patient relationship and foster healthcare autonomy as teenagers approach adulthood. While most of the basic components of the physical exam in adolescents are similar to those in adults, there is an added focus on pubertal development through the use of the Sexual Maturity Rating scale. Important adolescent psychosocial screening questions,...
01:18
Cognitive Development During Adolescence
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2025
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the recognition that people have...
FAQs
Ovarian hormone fluctuations provide a biological variable for examining how reproductive maturation relates to behavior, metabolism, and neural development. Because these changes occur alongside brain and endocrine maturation, researchers can assess whether observed outcomes reflect coordinated developmental processes rather than isolated changes in one organ system. This makes hormone-related timing important when interpreting adolescent biology experiments.
Age helps distinguish developmental effects from differences caused by unrelated experimental conditions. During adolescence, maturation is progressing across several systems at once, so even small age differences may correspond to changes in reproductive status, neural development, stress responses, or metabolism. Consistent age selection improves comparisons among animals and strengthens the reproducibility of biological findings.
Reproductive status helps researchers account for biological variation associated with the transition toward maturity. It can influence how ovarian hormones relate to behavior, metabolism, and neural processes, making it relevant when comparing experimental groups. Recording and controlling this factor allows investigators to separate developmental physiology from effects produced by housing, treatment, or other experimental conditions.
A sound design should control age, housing, reproductive status, and other experimental conditions identified by the study. These factors can otherwise introduce environmental or developmental differences that resemble treatment effects. Keeping them consistent, or documenting them clearly when variation is intentional, helps investigators attribute changes more confidently to the biological question under examination.
These animals support investigations of puberty, sex-specific physiology, stress responses, nutrition, learning, and vulnerability to disease or drug exposure. Their value comes from allowing several developmental systems to be examined during the same life stage. Studies can therefore connect reproductive maturation with behavioral, metabolic, endocrine, or neural outcomes within a biological framework.
Experiments can reveal how adolescent development relates to behavior, metabolism, learning, stress responses, and neural changes, while also identifying effects associated with disease or drug exposure. The model is especially informative when investigators interpret outcomes alongside age, reproductive status, and housing conditions. Such comparisons improve the biological relevance and reproducibility of conclusions.