Great Saphenous Vein
Great Saphenous Vein - Related Videos
05:27
Drawing Blood from Rats through the Saphenous Vein and by Cardiac Puncture
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Cited by 87 •
2007
Blood draws are necessary in a large number of studies, for example to study the pharmacokinetics profile of a compound. Here, we demonstrate how to draw blood from rats using two techniques: blood draw from the saphenous vein or by cardiac puncture.
11:35
Decellularization and Recellularization Methodology for Human Saphenous Veins
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Cited by 21 •
2018
Here, we describe a protocol for the saphenous vein decellularization using detergents and recellularization by perfusion of the peripheral blood and the endothelial medium.
09:50
Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
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Cited by 9 •
2014
The mechanisms leading to the development of intimal hyperplasia (IH) and vein graft failure are still poorly understood. This study describes an ex vivo system to perfuse human veins under controlled flow and pressure. Furthermore the efficiency of external mesh reinforcement to limit the development of IH was evaluated.
00:09
Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
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2019
Presented here is a protocol for antegrade endoscopic vein harvesting from the lower leg, which can safely be introduced in routine coronary artery bypass grafting. Vein grafts present excellent graft quality following this standardized protocol with positioning of the legs, minimally invasive access to the vein, and antegrade endoscopic vein harvesting.
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Cited by 1 •
2022
Here, we present a protocol to treat the great saphenous vein (GSV) and the small saphenous vein (SSV) affected by severe pathological reflux, using an original sclerosing and embolizing cyanoacrylate-based glue composed of N-butyl cyanoacrylate and methacryloxy sulfolane (NBCA+MS).
FAQs
One-way valves help prevent blood from moving backward, while contractions of nearby skeletal muscles compress the vein and assist upward flow. This coordination is especially important in the lower limb, where blood must travel against gravity. When these mechanisms do not maintain effective venous return, blood can accumulate in the superficial venous system and contribute to venous insufficiency.
The saphenofemoral junction marks the connection between the superficial great saphenous vein and the deeper femoral vein. It provides an important transition point for blood returning from the lower limb toward the heart. Its location also gives clinicians a useful anatomical landmark when evaluating venous circulation, varicose veins, or other abnormalities affecting lower-limb drainage.
Venous return depends on the coordinated action of valve direction, surrounding skeletal-muscle contractions, and the vein’s course from the foot toward the thigh. Because the vessel ascends along the inner lower limb, blood flow must overcome gravitational pressure. Changes that impair valve function or reduce the effectiveness of the muscle pump can make upward transport less efficient.
If one-way control becomes ineffective, blood may move backward or remain within the superficial venous pathway instead of progressing efficiently toward the femoral vein. Persistent pooling increases the relevance of the great saphenous vein in varicose veins and venous insufficiency. Its long, accessible course helps explain why changes along this vessel can affect visible lower-limb circulation.
Its predictable course along the medial foot, inner leg, and thigh provides a surface-related anatomical pathway for vascular assessment. Clinicians can relate findings in these regions to superficial venous drainage and to the saphenofemoral junction. Examination of this pathway supports evaluation of varicose veins, venous insufficiency, and the broader pattern of lower-limb venous return.
The great saphenous vein can serve as an autologous graft, meaning tissue taken from the same individual, in reconstructive and cardiovascular surgery. Its importance in this context arises from its established role as a substantial superficial vessel with a clinically recognized anatomical course. Surgical use connects lower-limb venous anatomy with procedures that restore or reconstruct vascular pathways.
Study of this vessel links several biological concepts: superficial venous anatomy, one-way flow, skeletal-muscle assistance, and the movement of blood against gravity. Clinically, the same anatomy helps explain venous insufficiency and varicose veins while supporting vascular examination. It also provides context for understanding why a lower-limb vein may be selected for autologous grafting.