Infant Gut Microbiome
Infant Gut Microbiome - Related Videos
10:51
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
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Cited by 68 •
2016
We describe an in vitro protocol to co-culture gut microbiome and intestinal villi for an extended period using a human gut-on-a-chip microphysiological system.
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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Cited by 10 •
2023
neuroHuMiX is an advanced gut-on-a-chip model to study the interactions of bacterial, epithelial, and neuronal cells under proximal and representative co-culture conditions. This model allows unravelling of the molecular mechanisms underlying the communication between the gut microbiome and the nervous system.
08:38
Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
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2023
Caenorhabditis elegans is a powerful model to examine the molecular determinants driving host-microbiome interactions. We present a high throughput pipeline profiling the single animal levels of gut microbiome colonization together with key aspects of the C. elegans physiology.
07:25
Habituation: Studying Infants Before They Can Talk
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2023
Source: Laboratories of Nicholaus Noles, Judith Danovitch, and Cara Cashon—University of Louisville Infants are one of the purest sources of information about human thinking and learning, because they’ve had very few life experiences. Thus, researchers are interested in gathering data from infants, but as participants in experimental research, they are a challenging group to study. Unlike older children and adults, young infants are unable to reliably speak, understand speech, or even move and...
12:55
P50 Sensory Gating in Infants
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Cited by 5 •
2013
Methods to record auditory P50 sensory gating, a physiological marker of cerebral inhibition which reflects early stages of attention, are described.
FAQs
Microbial metabolites provide a chemical link between gut microorganisms and the infant’s biology. They can interact with intestinal cells and the developing immune system, potentially influencing gut barrier function and immune development. Examining these interactions helps biologists connect changes in microbial communities with early-life effects on intestinal stability and later susceptibility to disease.
Feeding is one of the early-life conditions that can alter the composition and activity of the infant gut microbiome. Changes associated with feeding may affect which microorganisms become established and how they process nutrients. Studying these relationships helps researchers evaluate nutrition as a factor shaping gut development, microbial metabolites, and interactions with intestinal cells.
Medications and other environmental factors can change microbial communities while the gastrointestinal tract and immune system are still developing. These changes may influence microbial activity, metabolite production, nutrient processing, and gut barrier function. In biology research, tracking such influences helps clarify how early-life conditions may contribute to differences in health or susceptibility to disease.
Researchers examine the microorganisms present in the infant gastrointestinal tract and relate community changes to biological outcomes such as gut barrier function, nutrient processing, immune development, and disease susceptibility. They can also consider birth-related exposure, feeding, medications, and environmental conditions. This approach connects microbial colonization patterns with the developmental processes occurring in early life.
Probiotics are investigated as a possible strategy for promoting healthy development by influencing early microbial communities. Research can assess whether probiotic interventions are associated with changes in gut microorganisms, metabolite interactions, nutrient processing, or barrier and immune development. The broader goal is to understand how nutrition-related approaches might support beneficial biological outcomes in infancy.
Antibiotic effects are important because medications can influence microbial communities during a period of rapid gastrointestinal and immune development. Studies of this topic examine how medication exposure relates to microbial changes and downstream features such as nutrient processing, metabolite interactions, gut barrier function, and disease susceptibility. These findings support evaluation of early-life conditions that may affect health.