Liver Injury
Liver Injury - Related Videos
07:27
The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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Cited by 14 •
2017
Here we describe a common method to induce chronic liver injury in mice by feeding of a choline-deficient and ethionine-supplemented (CDE) diet. We demonstrate health monitoring, liver perfusion, isolation, and preservation. A time course of six weeks can inform about liver injury, pathohistology, fibrosis, inflammatory, and liver progenitor cell responses.
10:45
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
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Cited by 27 •
2017
This protocol describes histological analyses of the livers from zebrafish larvae that have been treated with 2% ethanol for 24 h. Such acute ethanol treatment results in hepatic steatosis and swelling of the hepatic vasculature.
04:24
Bipolar Radiofrequency-Based Hemorrhage Arrest in Solid Organ Injury: A Technique to Arrest Bleeding in Porcine Model With Liver Injury Using Electrosurgery
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2025
This video demonstrates a technique of bipolar radiofrequency energy-based transcollation for hemorrhage arrest in solid organ injury in a porcine model. This method is helpful for the surgical management of traumatic injury by achieving hemostasis by arresting bleeding at the injury site.
08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Cited by 300 •
2015
Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.
12:35
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
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Cited by 14 •
2011
The study of liver sinusoidal endothelial cells (SECs) must be performed with primary cells obtained from the animal as no cell lines exist. This method relies on liver digestion and differential centrifugation for SEC purification for subsequent culturing and experimentation.
FAQs
Cellular stress can initiate oxidative damage, which is accompanied by inflammation in injured liver tissue. If the process becomes severe, affected cells may die, and the resulting tissue response can include fibrosis. These linked events matter because they connect an early cellular disturbance with structural changes that may compromise recovery and contribute to disease progression.
Fibrosis represents a downstream outcome associated with extensive injury and changes in liver tissue. The overview links cell death and fibrosis with severe disease and identifies prevention of progression to cirrhosis as a therapeutic goal. Studying this transition therefore helps researchers connect injury severity with long-term loss of liver function.
Toxins and medications can expose liver cells to damaging substances, whereas infections and immune-mediated disease involve different biological triggers. Impaired blood flow adds a vascular cause of tissue stress. Comparing these causes helps researchers investigate why similar liver dysfunction may arise through distinct pathways and supports efforts to identify the source of injury before evaluating recovery.
Evaluation combines symptoms, liver enzyme biomarkers, imaging, and histological analysis. Symptoms provide clinical context, while biomarkers offer measurable evidence of liver disturbance; imaging and tissue analysis add structural information. Using these approaches together helps researchers and clinicians investigate possible causes and evaluate recovery.
In drug toxicity research, Liver Injury provides a biological context for examining whether medication exposure is associated with cellular stress, inflammation, cell death, or fibrosis. Investigators can pair this mechanistic focus with enzyme biomarkers, imaging, and histological analysis. The resulting evidence helps evaluate harmful effects and informs strategies intended to preserve liver function.
Because assessment can evaluate recovery, liver injury studies provide a way to examine how damaged tissue responds after the initiating problem. In biology, this work connects cellular stress, inflammation, cell death, and fibrosis with broader questions about tissue repair. It also supports research on chronic liver disease and therapies designed to preserve function and limit cirrhosis progression.