Receptor Cells
Receptor Cells - Related Videos
10:14
Retroviral Transduction of T-cell Receptors in Mouse T-cells
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Cited by 21 •
2010
We present a protocol to produce antigen-specific mouse T-cells using retroviral...
04:24
Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
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Cited by 3 •
2011
We describe a protocol to observe and analyze cell rolling trajectories on asymmetric receptor-patterned substrates. The resulting data are useful for engineering of receptor-patterned substrates for label-free cell separation and analysis.
01:28
Types of Receptors: Cell Surface Receptors
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2023
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
04:55
Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells
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Cited by 6 •
2011
Here we demonstrate a protocol to carry out live cell staining that can be used to detect odorant receptors on the surface of HEK293T cells conveniently. In addition, it may also be used to assay for surface expression of other chemosensory receptors or GPCRs.
04:38
An Ex Vivo Technique to Manufacture Chimeric Antigen Receptor T Cells
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2025
This video demonstrates a technique to manufacture chimeric antigen receptor (CAR) T cells ex vivo. Human T cells are incubated with magnetic beads coated with anti-CD3 and anti-CD28 antibodies, along with a medium supplemented with interleukin-2 (IL-2), leading to T cell activation and proliferation. Transgenic lentiviral vectors are introduced, allowing the transgenic RNA to integrate into the host genome and express the transgene. This results in the transduced T cells expressing chimeric...
FAQs
A stimulus first activates receptor proteins or ion channels in the cell membrane. Their activity changes the membrane potential, which converts the environmental or physiological change into an electrical signal. Depending on the receptor-cell system, this altered electrical state can also trigger neurotransmitter release, allowing the information to enter neural communication pathways for perception, reflexes, or regulation.
Receptor proteins and ion channels provide the molecular link between a stimulus and a cellular response. Light, sound, pressure, chemicals, or temperature can activate these components, producing a change in membrane potential. That change determines whether the receptor cell generates an electrical signal or releases neurotransmitters, so these components strongly influence how sensory information is encoded for the body.
Signals from receptor cells can contribute to conscious perception, but they can also initiate responses without requiring conscious awareness. Once sensory transduction produces an electrical signal or neurotransmitter release, the resulting information can participate in reflexes or physiological regulation. This allows the body to respond to relevant internal or external changes as well as interpret them as sensory experiences.
Researchers examine how receptor cells respond when receptor proteins or ion channels are activated by relevant stimuli. They can focus on changes in membrane potential, electrical signaling, or neurotransmitter release to follow sensory transduction. These observations connect cellular events with neural communication and help clarify how particular sensory systems support perception, reflexes, or physiological regulation.
Receptor cells provide a cellular target for studying how sensory information is detected and transmitted. Their signaling mechanisms can be examined in relation to dysfunction, sensory loss, or neurological disease. This research context supports diagnostic investigation, pharmacology studies, and the development of therapeutic approaches aimed at understanding or addressing disrupted sensory and neural communication.
When receptor-cell signaling is disrupted, the effects may include sensory loss or broader neurological disease. Studying whether the problem involves stimulus detection, membrane-potential changes, electrical signaling, or neurotransmitter release helps relate cellular dysfunction to impaired communication in the nervous system. This connection makes receptor cells relevant to investigating disease mechanisms and potential therapies.