Tissue Strain Mapping
Tissue Strain Mapping - Related Videos
10:24
Quantitative Strain Mapping of an Abdominal Aortic Aneurysm
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2023
Source: Hannah L. Cebull1, Arvin H. Soepriatna1, John J. Boyle2 and Craig J. Goergen1 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 2Mechanical Engineering & Materials Science, Washington University in St. Louis, St Louis, Missouri The mechanical behavior of soft tissues, such as blood vessels, skin, tendons, and other organs, are strongly influenced by their composition of elastin and collagen, which provide elasticity and strength. The fiber...
09:29
Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens
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Cited by 19 •
2016
We describe the use of digital image correlation to characterize the local surface strain field on vascular tissue samples subjected to uniaxial tensile testing. These measurements facilitate precise quantification of the sample mechanical response and the generation of constitutive stress-strain relations.
02:58
Measurement of Compressive Stress-Strain Response at Small-Strains
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2025
This protocol presents the configuration of a compression test device capable of precisely measuring the mechanical properties of microstructures in the small-strain region, along with a systematic method for compression testing using this device. The proposed device can be used to analyze various microstructures and the mechanical behavior of polymer-based materials.
10:17
Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
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Cited by 18 •
2014
Laser-induced breakdown spectroscopy performed on thin organ and tumor tissue successfully detected natural elements and artificially injected gadolinium (Gd), issued from Gd-based nanoparticles. Images of chemical elements reached a resolution of 100 μm and quantitative sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes its potential to provide multiple images of a same biological tissue.
06:58
Fate Mapping
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2023
Fate mapping is a technique used to understand how embryonic cells divide, differentiate, and migrate during development. In classic fate mapping experiments, cells in different areas of an embryo are labeled with a chemical dye and then tracked to determine which tissues or structures they form. Technological improvements now allow for individual cells to be marked and traced throughout embryonic development and adulthood. This video reviews the concepts behind fate mapping, and then details a...
FAQs
The method first compares a reference state with a deformed state, using identifiable features or image patterns as spatial landmarks. Their movement provides local displacement values, and those values are used to calculate strain at different locations. The resulting spatial variation shows which parts of a tissue deform more or less under loading.
Local strain patterns reveal how mechanical forces are distributed rather than treating the tissue as mechanically uniform. Regions with concentrated deformation can be distinguished from areas that share or accommodate less strain. In biology, this distinction helps relate the behavior of cells, extracellular matrix, and larger tissue regions to function.
By placing deformation measurements alongside tissue structure, Tissue Strain Mapping helps researchers examine how organization relates to mechanical behavior. This relationship is important when tissues change during growth, development, injury, or disease. The maps therefore provide a way to connect visible tissue patterns with responses to loading and biological function.
A basic workflow begins by selecting a reference state and a corresponding deformed state, then identifying features or image patterns that can be followed between them. Researchers calculate displacement from feature movement and convert those measurements into local strain values. Mapping those values across the tissue produces a spatial view of deformation.
In biology, the technique supports questions in morphogenesis, biomechanics, wound healing, and tissue engineering. It can show how different tissue regions respond while the tissue is loaded or changes during biological processes. This makes the measurements useful for relating mechanical behavior to processes such as shaping, repair, and engineered tissue function.
Maps can identify where deformation is concentrated and where forces are shared among cells, extracellular matrix, and tissue regions. In injury and disease studies, that information helps characterize altered mechanical behavior and relate it to tissue organization. In developmental studies, it can clarify how mechanical forces accompany morphogenesis.