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Laser-induced Breakdown Spectroscopy

Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue

Article DOI: 10.3791/51353-v 10:17 min June 18th, 2014
June 18th, 2014



Laser-induced breakdown spectroscopy performed on thin organ and tumor tissue successfully detected natural elements and artificially injected gadolinium (Gd), issued from Gd-based nanoparticles. Images of chemical elements reached a resolution of 100 μm and quantitative sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes its potential to provide multiple images of a same biological tissue.


Laser-induced Breakdown Spectroscopy LIBS Nanoparticle Mapping Nanoparticle Quantification Organ Tissue Analysis Emission Spectroscopy Elemental Analysis Inorganic Elements Gadolinium-based Nanoparticles Two-dimensional Scan Lateral Resolution Chemical Imaging Sub-mM Sensitivity Distribution Of Inorganic Materials Standard Optical Microscopy
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