Wisdom Teeth

Wisdom teeth are the third and final set of molars, developing at the back of the mouth and contributing to the biology of human dentition. They form within the jaw during late adolescence or early adulthood as tooth tissues mineralize and the roots develop, followed by eruption through the gums; limited jaw space can prevent normal alignment and cause impaction. Studying wisdom teeth helps explain tooth development, craniofacial growth, and evolutionary changes in human jaws. Clinically, their position and eruption status guide monitoring and decisions about treatment, including removal when they contribute to pain, infection, decay, or damage to neighboring teeth.

Wisdom Teeth - Related Videos

Research

JoVE Journal - Biology

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

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Cited by 24 •

2013

We developed computational de novo protein design methods capable of tackling several important areas of protein design. To disseminate these methods we present Protein WISDOM, an online tool for protein design (http://www.proteinwisdom.org). Starting from a structural template, design of monomeric proteins for increased stability and complexes for increased binding affinity can be performed.

Education

JoVE Core - Anatomy and Physiology

Teeth

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2024

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage. In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

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Cited by 100 •

2012

The method described isolation and characterization of human Dental Pulp Stem Cells (hDPSCs) by using either enzymatic dissociation of pulp (DPSC-ED) or direct outgrowth of stem cells from pulp tissue explants (DPSC-OG). Then followed by in vitro comparative differentiation of both types of hDPSCs into odontoblasts.

Isolation of Gingival Immune Cell Network from Murine Teeth Blocks

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2025

This video demonstrates the isolation procedure of the gingival immune cell network from a mouse model. The enzymatic digestion releases the gingival tissue from the attached teeth and bone, which is further mechanically digested, releasing immune cells from the gingiva. The isolated cells are ready for immunological experiments.

Research

JoVE Journal - Developmental Biology
Free Sample

Rapid Isolation of Single Cells from Mouse and Human Teeth

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Cited by 3 •

2021

The current protocol presents a fast, efficient, and gentle method for isolating single cells suitable for single-cell RNA-seq analysis from a continuously growing mouse incisor, mouse molar, and human teeth.

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