En Bloc Retrieval
En Bloc Retrieval - Related Videos
10:01
En Face Preparation of Mouse Blood Vessels
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Cited by 20 •
2017
A procedure for making en face preparations of the mouse carotid artery and aorta is described. Such preparations, when immunofluorescently stained with specific antibodies, enable us to study localization of proteins and identification of cell types within the entire vascular wall by confocal microscopy.
08:42
Retrieval of Mouse Oocytes
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Cited by 13 •
2007
This protocol illustrates the technique for extracting oocytes or early-stage fertilized embryos from the oviduct of mice. The ability to identify the infindibulum and insert a blunt end needle into it is essential to correctly performing the procedure.
01:12
Retrieval
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2025
Retrieval is the process of getting information out of memory storage and back into conscious awareness. This ability is essential for daily tasks like brushing hair and teeth, driving to work, and performing job duties. Retrieval occurs in three ways: recall, recognition, and relearning. Recall involves accessing information without cues, such as during an essay test, where individuals must retrieve facts and concepts from memory unaided. Another example is remembering the name of a colleague...
07:37
Roux-en-Y Gastric Bypass Operation in Rats
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Cited by 48 •
2012
Numerous studies using gastric bypass rat models have been recently conducted to uncover the underlying physiological mechanisms of Roux-en-Y gastric bypass operations. This article aims to demonstrate and discuss the technical and experimental details of our published gastric bypass rat model to understand advantages and limitations of this experimental tool.
05:52
Deployment and Retrieval of Mineral Samplers
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2026
Many important reactive minerals are formed during in situ groundwater remediation; however, conventional drill core-based methods often present challenges in collecting these minerals. This article offers techniques for utilizing the Min-Trap, an innovative passive sampling device, to effectively collect and measure reactive minerals from conventional monitoring wells.
FAQs
The planned dissection or resection boundary is central to en bloc retrieval because it separates the target from surrounding tissue while maintaining its internal organization. Preserving that spatial arrangement allows investigators to examine how different parts of a lesion relate to one another and to the tissues at its edge, rather than interpreting disconnected fragments whose original positions are less clear.
An intact specimen gives histopathological examination access to tumor architecture, meaning the organized arrangement of cells and tissue within the lesion. That organization can be considered alongside the specimen’s margins and adjacent-tissue relationships. Fragmentation may make those relationships harder to evaluate, so intact retrieval supports a more complete interpretation of the lesion’s structural features.
Preserving the tumor together with relevant surrounding tissue helps investigators evaluate the lesion’s margins, its relationship with adjacent structures, and whether invasion extends beyond the main tumor. These observations contribute to histopathological interpretation and can support cancer staging, which in turn may influence treatment decisions and the assessment of disease extent.
The procedure begins by identifying a planned dissection or resection boundary around the tissue specimen, lesion, or tumor. The target is then separated from surrounding tissue along that boundary and extracted as an intact piece. Avoiding disruption during removal preserves the specimen’s internal organization for subsequent examination of architecture, margins, invasion, and tissue relationships.
An intact specimen can support evaluation of tumor architecture, margin status, invasion, and the tumor’s relationships with adjacent tissues. Together, these features provide material for more accurate histopathological interpretation and can inform staging and treatment decisions. The preserved organization also gives researchers a stronger basis for examining tumor biology within its tissue context.
In cancer research, preserved specimens can provide better-organized material for studying tumor biology and for evaluating emerging diagnostic or therapeutic approaches. Maintaining the relationships among the tumor, its margins, and nearby tissues helps researchers connect structural findings with biological questions. This makes the approach relevant both to pathology-focused investigations and to development of new cancer methods.