Hand-held Homogenizer
Hand-held Homogenizer - Related Videos
09:43
Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
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Cited by 10 •
2017
A clinical handheld photoacoustic imaging system will be demonstrated for real-time non-invasive small animal imaging.
01:23
Test for Homogeneity
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2023
The goodness–of–fit test can be used to decide whether a population fits a given distribution, but it will not suffice to decide whether two populations follow the same unknown distribution. A different test, called the test for homogeneity, can be used to conclude whether two populations have the same distribution. To calculate the test statistic for a test for homogeneity, follow the same procedure as with the test of independence. The hypotheses for the test for homogeneity can be stated as...
09:56
Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
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Cited by 20 •
2014
We provide herein a detailed description of the experimental protocol for imaging with a newly developed hand-held optoacoustic (photoacoustic) system for three-dimensional functional and molecular imaging in real time. The demonstrated powerful performance and versatility may define new application areas of the optoacoustic technology in preclinical research and clinical practice.
08:09
The Rubber Hand Illusion
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Reaching for objects, walking without hitting obstacles, landing on a chair as you sit (instead of falling to the floor), these and all our physical actions depend on an ability to perceive our own bodies in space, to know where our limbs are relative to one another and relative to the rest of the world. One way that the human brain encodes this information is called proprioception, the brain relies on its own control and feedback...
04:16
ECM Suspension Preparation: A Technique to Obtain Homogenous Suspension from Tissue-derived Extracellular Matrix
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2023
This video describes the preparation of a homogenized and digested extracellular matrix suspension from decellularized and lyophilized tissues. This technique helps in fabricating ECM-derived porous foams and microcarriers for use as substrates in advanced 3D cell culture models.
FAQs
During operation, the rotating probe transfers mechanical energy into the specimen. High-speed rotation creates shear and turbulence, which break tissue apart, disperse cells, and mix components throughout the sample. This action matters because downstream DNA, RNA, or protein extraction depends on obtaining material that is sufficiently uniform for representative molecular and biochemical analysis.
Probe size, operating time, and sample volume are key control variables. The probe must be considered in relation to the amount of material being processed, while operating time determines how long the specimen experiences mechanical disruption. Adjusting these factors helps produce a consistent homogenate rather than an uneven sample, supporting comparable measurements across specimens.
Uniformity helps distribute tissue, cells, and sample components more evenly before extraction or assay preparation. When specimens are processed consistently, measurements of DNA, RNA, or proteins are more comparable between samples. This is especially important in cancer research, where differences in sample preparation could complicate interpretation of molecular profiles, biomarkers, or biochemical assay results.
A typical workflow begins by mechanically processing a tumor biopsy, cultured-cell sample, or other specimen with the rotating probe. The resulting homogenate is then used for DNA, RNA, or protein extraction. Those extracts can proceed to molecular profiling, biomarker analysis, or biochemical assays, linking bench-top sample preparation with downstream cancer research measurements.
Cancer researchers can use this device with tumor biopsies, cultured cells, and other biological specimens that require mechanical disruption before analysis. Processing these materials at the bench can prepare them for extraction and subsequent molecular or biochemical studies. The approach therefore supports work with both tissue-derived samples and cell-based experimental systems.
After consistent preparation, homogenized samples can support DNA, RNA, and protein extraction. These materials may then be examined through molecular profiling, biomarker analysis, and biochemical assays. The resulting measurements can help researchers characterize specimens and evaluate molecular features, while reproducible homogenization improves confidence that observed differences reflect the samples rather than inconsistent preparation.