Cyclic Ketone Synthesis
Cyclic Ketone Synthesis - Related Videos
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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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A protocol for the synthesis and characterization of diffusive motion of cyclic polymers at the single molecule level is presented.
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Cyclic Voltammetry (CV)
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2023
Source: Laboratory of Dr. Kayla Green — Texas Christian University A Cyclic Voltammetry (CV) experiment involves the scan of a range of potential voltages while measuring current. In the CV experiment, the potential of an immersed, stationary electrode is scanned from a predetermined starting potential to a final value (called the switching potential) and then the reverse scan is obtained. This gives a 'cyclic' sweep of potentials and the current vs. potential curve derived from the data is...
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Identification of Unknown Aldehydes and Ketones - Concepts
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2020
Aldehydes and Ketones Aldehydes and ketones have a carbonyl group (C=O) as a functional group. A ketone has two alkyl or aryl groups attached to the carbonyl carbon (RCOR’). The simplest ketone is acetone, which has two methyl groups attached to the carbonyl carbon (CH3COCH3). An aldehyde is similar to a ketone, except that instead of two side groups connected to the carbonyl carbon, they have at least one hydrogen (RCOH). The simplest aldehyde is formaldehyde (HCOH), as it has two hydrogens...
15:03
Identification of Unknown Aldehydes and Ketones - Student Protocol
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2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA DNPH Test for Aromatic Aldehydes and KetonesExpand In this lab, you'll use the DNPH test, the Tollens' test, and the iodoform test to identify two unknown aldehydes or ketones. You'll use butanone and benzaldehyde as known compounds to confirm that the tests are working as expected. You'll start the lab with the DNPH test, which relies on the reaction between 2,4-dinitrophenylhydrazine, or DNPH,...
07:12
Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
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Cited by 7 •
2011
A cyclic pressure bioreactor capable of subjecting heart valve tissue to physiological and pathological pressure conditions has been designed. A LabVIEW program allows users to control pressure magnitude, amplitude and frequency. This device can be used to study the mechanobiology of heart valve tissue or isolated cells.
FAQs
Ring closure depends strongly on the intended ring size and the substitution pattern around the forming bond. In cyclic ketone synthesis, these structural features can affect whether intramolecular acylation or enolate alkylation proceeds as intended, while also influencing competing pathways. Designing the precursor therefore requires matching its connectivity to a feasible carbon-carbon bond-forming event.
Intramolecular acylation and enolate alkylation provide different ring-closing strategies. The former uses an acylation-based carbon-carbon bond formation, whereas the latter relies on enolate alkylation to close the ring. Choosing between them depends on the substrate’s connectivity and on whether the carbonyl should be installed during closure or preserved for later chemistry.
Oxidation offers a complementary route when the starting material is a cyclic secondary alcohol. Rather than creating the ring through a new closure, this approach converts the existing alcohol-containing ring into a ketone. It is therefore useful when the cyclic framework is already available, while ring-closing methods are more relevant when the framework itself must be assembled.
A practical planning sequence begins by selecting the desired ring size and substitution pattern, then designing a precursor for intramolecular acylation or enolate alkylation. The synthesis must account for carbonyl installation or preservation during ring closure and for chemoselectivity. If a cyclic secondary alcohol is available instead, oxidation can provide the ketone-forming step.
Their carbonyl groups support further functionalization, so a single ring-forming operation can contribute to the construction of more elaborate molecular frameworks. This utility explains their relevance to pharmaceutical and natural-product synthesis, as well as to broader organic research and industrial chemistry, where controlled assembly of complex structures is important.
Evaluation should consider whether the planned ring size and substitution pattern were achieved, whether the carbonyl group was installed or retained as intended, and whether chemoselectivity was maintained. Competing pathways are also important because they can divert the reaction from the desired cyclic ketone. These criteria connect structural design with the quality of the synthetic outcome.