Nanostructured Lipid
Nanostructured Lipid - Related Videos
07:53
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
0 Views •
Cited by 8 •
2016
The most commonly used method for nanostructured lipid carrier (NLC) synthesis involves oil-in-water emulsion, homogenization and solidification. This was modified here by applying high shear dispersion after solidification to achieve a NLC with desirable size, improved drug encapsulation and drug loading efficiency as a potential carrier for dacarbazine delivery.
12:35
Atomically Traceable Nanostructure Fabrication
0 Views •
Cited by 4 •
2015
We report a protocol for combining the atomic metrology of the Scanning Tunneling Microscope for surface patterning with selective Atomic Layer Deposition and Reactive Ion Etching. Using a robust process involving numerous atmospheric exposures and transport, 3D nanostructures with atomic metrology are fabricated.
09:47
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
0 Views •
Cited by 17 •
2016
We report on a smart application of carbon nanotubes for kinetic stabilization of lipid particles that contain self-assembled nanostructures in their cores. The preparation of lipid particles requires rather low concentrations of carbon nanotubes permitting their use in biomedical applications such as drug delivery.
12:22
Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
0 Views •
Cited by 5 •
2016
Nanoscaled sea-island surfaces composed of thermoresponsive block copolymers were fabricated by the Langmuir-Schaefer method for controlling spontaneous cell adhesion and detachment. Both the preparation of the surface and the adhesion and detachment of cells on the surface were visualized.
02:52
Assessing the Antibacterial Activity of Nanostructured Surfaces Using a Focused-Contact Exposure Method
0 Views •
2026
Source: Holt-Torres, P. S. et al. Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro. J. Vis. Exp. (2023)This video demonstrates the use of the focused-contact exposure method to evaluate the antibacterial activity of nanostructured surfaces. It outlines the steps involved in establishing direct contact between bacteria and the nanostructured surface, incubation, bacterial collection, and colony counting to assess viability.
FAQs
In aqueous environments, amphiphilic lipids arrange themselves so that their water-compatible regions interact with the surrounding liquid while their hydrophobic regions associate away from it. This self-assembly is driven primarily by hydrophobic interactions. The resulting organization creates internal lipid domains that can accommodate compounds with different solubility characteristics.
Surfactants and other surface-active components help stabilize the organized lipid structure at its interface with the aqueous environment. Their presence can support the formation and persistence of the system by influencing interactions between lipid regions and water. In chemistry, this stabilization is important because structural persistence affects how the material transports, protects, and releases incorporated molecules.
Size, composition, and organization determine how the material behaves physically and chemically. Changes in these structural features can influence interactions with water, the accommodation of water-soluble or lipid-soluble compounds, and the way active molecules are released. Consequently, researchers consider these variables when designing lipid-based systems for specific transport or formulation objectives.
Their organized lipid architecture can contain both water-soluble and lipid-soluble compounds, rather than restricting incorporation to one chemical class. Water-compatible regions provide an environment for water-soluble materials, while lipid-associated regions support lipid-soluble compounds. This dual accommodation expands the types of active molecules that can be incorporated into a single transport or release system.
A general workflow begins by combining lipid components with an aqueous environment, allowing amphiphilic molecules to self-assemble through hydrophobic interactions. Surface-active components may then help stabilize the resulting organization. The selected composition and structural conditions determine how compounds are incorporated and how the final system can support protection, transport, or controlled release.
Researchers may select these systems when an active molecule needs protection, transport, or regulated release. The lipid structure can incorporate compounds according to their solubility and provide an organized chemical environment for carrying them. This makes nanostructured lipids relevant to drug-delivery research, where formulation design focuses on managing how active molecules are presented and released.
Applications extend to cosmetic formulations and the design of advanced functional materials. In cosmetics, the systems can support incorporation and transport of selected active compounds within a lipid-based formulation. In materials research, their nanoscale organization and tunable composition provide a basis for developing functions that depend on controlled molecular incorporation and release.
Researchers can examine how composition, size, and organization relate to physical and chemical behavior. They can also assess whether the structure accommodates water-soluble or lipid-soluble compounds and whether it supports protection, transport, or controlled release. These observations connect molecular self-assembly with practical formulation performance in delivery, cosmetic, and materials applications.