Lung Collapse
Lung Collapse - Related Videos
03:18
In Vitro Assessment of Aggregated Amyloid-β on Neuronal Growth Cone Collapse
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2025
This video demonstrates an in vitro assessment of neuronal growth cone collapse by amyloid-β (Aβ) aggregates. Treating the neurons with Aβ aggregates causes cytoskeletal destabilization, leading to the collapse of growth cones at the tip of the axons. The treated cells are compared with control cells to assess the extent of growth cone collapse.
07:36
Angiogenesis in the Ischemic Rat Lung
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Cited by 3 •
2013
The lung is perfused by both the systemic bronchial artery and pulmonary arteries. In most lung pathologies, it is the smaller systemic vasculature that shows robust neovascularization. Cessation of pulmonary blood flow promotes brisk bronchial angiogenesis. We provide surgical details of inducing left pulmonary artery ischemia that promotes bronchial neovascularization.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
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Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
01:47
Lung Capacity
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2019
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures. There are four defined lung volume measures: tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume. Tidal volume is the amount of air inhaled and exhaled in a normal breath. Inspiratory...
FAQs
An obstructed airway prevents air from reaching the lung region beyond the blockage. As the trapped air is lost, that region cannot maintain its volume, so ventilation falls and gas exchange becomes less effective. Mucus plugging is one clinically relevant example, particularly after surgery, when shallow breathing can make airway clearance more difficult.
Surfactant helps alveoli remain open by supporting their stability. When surfactant is inadequate, alveoli are more likely to close, reducing the amount of ventilated lung tissue. This mechanism differs from collapse caused by an airway blockage or by pressure from air or fluid in the pleural space, although each can impair oxygen exchange.
Air or fluid in the pleural space can exert external pressure on adjacent lung tissue. That compression limits expansion and may reduce the air volume available for ventilation in the affected region. Because the mechanism is external rather than an airway blockage, clinical management focuses on identifying and addressing the pleural pressure contributing to the collapse.
Collapsed or poorly ventilated lung regions contribute less effectively to gas exchange. If enough lung tissue is affected, the body may receive less oxygen, producing possible oxygen deficiency. The degree of impact depends on the extent and cause of the collapse, which is why clinical assessment must connect observed findings with imaging and the underlying condition.
Assessment combines physical examination with chest imaging. The examination provides clinical findings that can prompt further evaluation, while imaging helps identify affected lung regions and supports investigation of possible causes. This combined approach is useful because treatment depends on whether the problem reflects airway obstruction, pleural pressure, shallow breathing, or another contributing clinical circumstance.
Management is selected according to the cause and may include airway-clearance measures, breathing exercises, oxygen support, or treatment directed at pleural pressure. After surgery, encouraging effective breathing and addressing mucus plugging may be particularly relevant. The clinical objective is to improve ventilation or correct the factor preventing the affected lung region from remaining open.