Lung Function
Lung Function - Related Videos
07:45
Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
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2025
This protocol provides instructions for intranasal administration of IAV and downstream analysis of mouse lung damage and associated transcriptional changes to lung cell types.
10:44
Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Cited by 4 •
2024
Three-dimensional (3D) phase-resolved functional lung (PREFUL) is a functional magnetic resonance imaging (MRI) technique that allows for quantification of regional ventilation of the whole human lung volume, using tidal breathing and contrast-agent free acquisition for 8 min. Here, we present an MR protocol to collect and analyze 3D PREFUL imaging data.
05:56
Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
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Cited by 8 •
2024
Here, we describe the implementation of phase-resolved functional lung MRI as a contrast-agent-free proton MR technique for the assessment of pulmonary ventilation and perfusion dynamics. Validated and applicable across different field strengths and age groups, it could enhance clinical decision-making in the future by aiding in disease quantification and therapy monitoring.
01:47
Lung Capacity
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2019
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures. There are four defined lung volume measures: tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume. Tidal volume is the amount of air inhaled and exhaled in a normal breath. Inspiratory...
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
FAQs
Within the alveoli, oxygen and carbon dioxide move across the respiratory membrane because each gas follows a difference in partial pressure. This pressure gradient provides the driving force for exchange rather than merely reflecting air movement. Effective ventilation brings air to the alveoli, allowing those gradients to support oxygen delivery and carbon dioxide removal during respiratory function.
The respiratory membrane is important because it forms the boundary across which oxygen and carbon dioxide are exchanged. Its thin structure places the gases at the interface between alveolar air and the exchange process, linking ventilation with blood-gas transfer. In clinical terms, this helps explain why assessing lung function requires more than considering airflow alone.
Ventilation and gas exchange describe connected but different stages. Ventilation moves air through the airways into the alveoli, whereas gas exchange uses partial-pressure differences to move oxygen and carbon dioxide across respiratory membranes. Separating these stages helps clinical assessment organize whether respiratory performance involves air movement, the exchange process, or both.
During spirometry, clinicians measure airflow and lung volumes rather than relying only on symptoms. The resulting measurements can be examined for obstructive or restrictive patterns. This makes the test useful for translating respiratory performance into quantitative findings, supporting evaluation of suspected or known disease and providing a basis for comparing lung function over time.
Testing is particularly relevant when symptoms suggest altered respiratory performance or when clinicians need to evaluate asthma or chronic obstructive pulmonary disease. The measurements can also be used to monitor disease, assess whether treatment is producing a response, and contribute to decisions about respiratory care. Its value therefore extends beyond a single diagnostic assessment.
Follow-up interpretation focuses on change as well as the initial pattern. Comparing lung-function measurements can support disease monitoring and help assess treatment response, while the broader clinical picture guides respiratory-care decisions. In this context, the numbers are not an isolated endpoint: they provide evidence that can be incorporated into ongoing evaluation of conditions such as asthma and chronic obstructive pulmonary disease.