Nail Clubbing

Nail clubbing is a physical sign in which the fingertips become enlarged and the nails curve around the expanded distal digits, making it clinically important as a possible indicator of underlying disease. It develops through changes in the nail bed and soft tissues, with increased vascularity, connective-tissue growth, and remodeling of the terminal phalanx contributing to loss of the normal nail-fold angle. In clinical practice, clinicians assess nail curvature, nail-bed fluctuation, and the profile angle, then interpret the finding alongside symptoms and other examination results. Clubbing can accompany pulmonary, cardiovascular, gastrointestinal, inflammatory, or malignant conditions, so recognizing it can guide further diagnostic evaluation.

Nail Clubbing - Related Videos

Education

JoVE Business - Microeconomics

Club Goods and Public Goods

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2025

Goods and services can be categorized based on their relative accessibility and the impact of individual consumption on other potential users. Two important classifications are club goods and public goods. These categories help explain how access to resources is managed and how their use impacts society. Club Goods Club goods are products or services that are excludable but non-rivalrous. This means that access to the good can easily be restricted, typically through a form of payment or...

Accessory Structures of the Skin: Nails

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2023

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity. The main components of a nail include the following. Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...

Research

JoVE Journal - Medicine

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice

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Cited by 10 •

2016

This protocol describes an osteosynthesis technique using an intramedullary locking nail for standardized fixation of femur osteotomies, which can be used to analyze normal and defective bone healing in mice.

Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner

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2025

Here, we present a protocol for accessing the guidewire of intramedullary femoral nailing in obese patients using an in-house designed awl. Using the new awl with a distal positioner for the guidewire insertion and opening the bone can increase efficiency in inserting the guidewire and reduce the difficulty of surgery.

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

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Cited by 33 •

2015

Scaffolds capable of fitting within cranio-maxillofacial (CMF) bone defects while exhibiting osteoconductivity and bioactivity are of interest. This protocol describes the preparation of a shape memory scaffold based on polycaprolactone diacrylate (PCL-DA) using a solvent-casting particulate-leaching (SCPL) method employing a fused salt template and application of a bioactive polydopamine coating.

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