Oxygen Therapy

Oxygen therapy is the controlled administration of supplemental oxygen to prevent or treat hypoxemia, a low level of oxygen in the blood, and support normal tissue function. Clinicians deliver oxygen through devices such as nasal cannulas, face masks, or mechanical ventilation, adjusting the flow or inspired oxygen concentration according to the patient’s condition and measured oxygen saturation. In clinical care, it can stabilize patients with respiratory illness, impaired gas exchange, or acute injury, while long-term use may support people with chronic lung disease. Careful titration is essential because inadequate oxygen leaves tissues at risk, whereas excessive exposure can cause harm in some settings.

Oxygen Therapy - Related Videos

Research

JoVE EoE - Neurotherapeutics

Hyperbaric Oxygen Therapy as a Neuroprotective Strategy for Anterior Ischemic Optic Neuropathy

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2025

Take a mouse subjected to laser-induced damage to the optic nerve head in the eye.The damage causes endothelial cell injury and blood clot formation in the blood vessels supplying the nerve, reducing blood flow and causing ischemia.Ischemia deprives the retinal ganglion cell axons in the optic nerve head of oxygen.In the RGC cell bodies, this disruption impairs mitochondrial function and increases reactive oxygen species production.The resulting oxidative stress activates apoptotic signaling...

Education

JoVE Core - Pharmacology

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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2024

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home. Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

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Cited by 278 •

2011

Here we propose simple methods to test and evaluate the presence of reactive oxygen species in cells.

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence

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Cited by 28 •

2011

We present an experimental procedure for measuring the partial pressure of oxygen (pO2) in cerebral vasculature based on oxygen-dependent quenching of phosphorescence. Animal preparation and imaging procedures were outlined for both large field of view CCD-based imaging of pO2 in rats and 2-photon excitation based imaging of pO2 in mice.

Detecting Reactive Oxygen Species

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2023

Reactive oxygen species are chemically active, oxygen-derived molecules capable of oxidizing other molecules. Because of their reactive nature, there are many deleterious effects associated with unchecked ROS production, including structural damage to DNA and other biological molecules. However, ROS can also be mediators of physiological signaling. There is accumulating evidence that ROS play significant roles in everything from activation of transcription factors to the mediation of...

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