Spect Ct Imaging
Spect Ct Imaging - Related Videos
09:08
Combined SPECT and CT Imaging to Visualize Cardiac Functionality
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2023
Source: Alycia G. Berman, James A. Schaber, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Here we will demonstrate the fundamentals of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging using mice. The technique involves injecting a radionuclide into a mouse, imaging the animal after it is distributed throughout the body, and then reconstructing the produced images to create a volumetric dataset. This can...
10:53
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
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Cited by 37 •
2012
A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.
11:18
Micro-CT Imaging of a Mouse Spinal Cord
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2023
Source: Peiman Shahbeigi-Roodposhti and Sina Shahbazmohamadi, Biomedical Engineering Department, University of Connecticut, Storrs, Connecticut It's a little-known fact that the discovery and (inadvertent) use of X-rays garnered the first ever Nobel Prize in Physics. The famous X-ray image of Dr. Röntgen's wife's hand from 1895 that sent shock waves through the scientific community looks like most modern day 2D medical X-ray images. Though it is not the newest technology, X-ray absorption...
09:49
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Cited by 10 •
2020
This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure overlapping.
08:57
High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
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Cited by 13 •
2011
Non-destructive volume visualization can be achieved only by tomographic techniques, of which the most efficient is the x-ray micro computerized tomography ( CT).
FAQs
CT-derived tissue maps support attenuation correction for the photon measurements collected by the rotating gamma cameras. Because the correction uses anatomical information from the same examination, the reconstructed three-dimensional activity distribution can be interpreted alongside tissue structure. This engineering link helps reduce ambiguity when abnormal physiology must be localized within specific anatomical regions.
After each modality produces its dataset, software registers the images so corresponding locations match. This multimodal alignment is essential because the functional signal and anatomical structures originate from different measurement systems. Accurate registration allows a detected activity distribution to be associated with a particular tissue region, supporting more precise interpretation than viewing either dataset independently.
The gamma-camera system must detect photons emitted by the administered radiotracer while rotating around the subject to support three-dimensional reconstruction. Its design therefore interacts with reconstruction software, CT measurements, and calibration procedures. In engineering terms, the useful result depends on coordinated hardware and computational processing rather than on the detector alone.
The process begins with administration of a gamma-emitting radiotracer, followed by rotating gamma-camera measurements and CT acquisition. The SPECT data are reconstructed into a three-dimensional activity distribution, while CT maps tissue structure and supplies information for attenuation correction. Software then registers both datasets, producing a fused image for interpretation.
The combined images can localize abnormal physiology in bone, cardiac, endocrine, and oncologic tissues. The functional component indicates where tracer-related activity is distributed, while the CT component places that activity within anatomical structure. This combination is useful when the research or clinical question requires both physiological information and precise structural localization.
SPECT/CT provides a concrete example of systems engineering in medical imaging. Detector design, photon detection, image reconstruction, CT-based attenuation correction, calibration, and multimodal data alignment must work together in one workflow. Studying these linked components helps explain how hardware, algorithms, and spatial registration jointly determine the usefulness of a fused medical image.