Hairless Mouse Model
Hairless Mouse Model - Related Videos
09:01
Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
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Cited by 4 •
2017
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
09:15
Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
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Cited by 8 •
2017
Here we describe a novel diabetic murine model utilizing hairless mice for real-time, non-invasive, monitoring of biofilm wound infections of bioluminescent Pseudomonas aeruginosa. This method can be adapted to evaluate infection of other bacterial species and genetically modified microorganisms, including multi-species biofilms, and test the efficacy of antibiofilm strategies.
06:24
Mouse Models of Periventricular Leukomalacia
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Cited by 28 •
2010
We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 17 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
09:01
Chronic Salmonella Infected Mouse Model
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Cited by 12 •
2010
Establish a chronic bacterial infected mouse model with persistent Salmonella typhimurium colonization in intestine for 27 weeks.
FAQs
Hairlessness and thymic deficiency represent different biological traits. A hairless mouse may retain an immunocompetent phenotype, whereas an athymic nude mouse is defined by impaired thymus-associated immune development. This distinction affects how investigators interpret host defense, inflammation, and pathogen responses, so the strain’s immune status must be confirmed rather than inferred from the absence of fur.
The mutation responsible for hairlessness disrupts hair-follicle development, creating a visible skin phenotype that can influence how researchers study cutaneous biology. It also provides practical access to the skin surface for examination and sampling. Investigators should distinguish effects associated with the altered follicular phenotype from responses caused by inoculation, injury, infection, or treatment.
Without fur obstructing the skin, investigators can examine lesion development more directly and follow visible changes over time. The same accessibility supports sampling and assessment of inflammatory responses after infection or injury. Consequently, the model helps connect surface findings with pathogen burden and immune measurements while reducing the visual interference that fur can create.
Investigators can inoculate the skin or other tissues with a pathogen, then monitor the resulting lesions, quantify pathogen burden, and measure inflammatory or immune responses. The exposed skin simplifies repeated visual assessment and supports collection of relevant samples. These readouts allow researchers to examine both microbial progression and host responses within the same experimental system.
The model supports studies of skin barrier function, wound healing, microbial pathogenesis, and host-pathogen interactions. It is also useful for evaluating topical therapies because investigators can apply treatments and directly observe associated cutaneous changes. These applications extend its value beyond infection alone, linking tissue integrity, repair, treatment response, and microbial challenge.
Researchers can directly monitor cutaneous changes after treatment and relate those observations to infection-associated lesions, pathogen burden, or inflammatory and immune responses. This combination helps evaluate whether a topical intervention corresponds with improved visible skin outcomes and altered host-pathogen measures. The accessible surface also facilitates examination and sampling during the study.