Intestinal Tumor Imaging
Intestinal Tumor Imaging - Related Videos
05:10
Three-dimensional Quantification of Intestinal Mucus Using Whole-mount Tissue Imaging
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2025
This study presents a 3D imaging method using whole-mount intestinal tissues and multi-photon microscopy to quantify secreted mucus, enabling precise volumetric analysis and visualization of mucus dynamics in response to stimuli like carbamoylcholine chloride.
14:04
Viral Nanoparticles for In vivo Tumor Imaging
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Cited by 45 •
2012
Plant viral nanoparticles (VNPs) are promising platforms for applications in biomedicine. Here, we describe the procedures for plant VNP propagation, purification, characterization, and bioconjugation. Finally, we show the application of VNPs for tumor homing and imaging using a mouse xenograft model and fluorescence imaging.
10:58
A Protocol for Lentiviral Transduction and Downstream Analysis of Intestinal Organoids
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Cited by 81 •
2015
In this video protocol we give a step by step explanation of lentiviral transduction in organoids of primary intestinal epithelium and of processing and downstream analysis of these cultures by quantitative RT-PCR, RNA-microarray and immunohistochemistry.
09:18
Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
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2026
This protocol uses a multichamber bed for parallel magnetic resonance imaging (MRI) of up to four animals to detect pancreatic adenocarcinoma tumors in genetically engineered mouse models. This multianimal MRI protocol is fast and cost-effective for detecting and measuring tumors, facilitating animal selection for preclinical studies and longitudinal monitoring of tumor growth.
09:04
In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles
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Cited by 13 •
2014
We describe a multi-angle rotational optical imaging (MAROI) system for in vivo quantitation of a fluorescent marker delivered by saposin C (SapC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Employing mouse models of cancer and arthritis, we demonstrate how the MAROI signal curve analysis can be used for the precise mapping and biological characterization of disease processes.
FAQs
Each modality emphasizes a different source of contrast. Endoscopy provides direct visualization of the gastrointestinal lining, while computed tomography and magnetic resonance imaging depict tissue structure. Ultrasound reflects tissue-related signal differences, and positron emission tomography can display metabolic or molecular-marker patterns. Combining these signals helps distinguish tumor characteristics that may not be apparent from a single imaging approach.
Repeated imaging creates a time-based record of tumor behavior rather than a single snapshot. Changes observed across examinations can indicate growth, disease progression, or response to treatment. In immunology and infection research, this temporal view also helps relate tumor development to evolving mucosal inflammation, immune-cell activity, and infection-associated changes within the intestinal environment.
Imaging can place tumor changes within the broader intestinal environment, where mucosal inflammation, immune-cell activity, and infectious processes may also alter tissue appearance or measurable signals. This relationship supports studies of how host defenses and infection-associated changes coincide with tumor behavior. The resulting observations can help researchers interpret tumor progression alongside immune and environmental changes.
These approaches provide complementary rather than interchangeable information. Endoscopy examines the gastrointestinal surface directly, whereas CT and MRI contribute structural views. Ultrasound offers another way to assess tissue-related differences, and PET can show metabolic or molecular-marker information. Selecting or combining methods allows imaging to address location, tumor characteristics, monitoring, or treatment planning according to the research question.
A useful workflow must first identify where a lesion or tumor is located, then characterize relevant features using an appropriate imaging method or combination of methods. Subsequent examinations can monitor changes over time. These outputs support diagnostic assessment and treatment planning, while consistent follow-up makes it possible to evaluate progression or response rather than relying only on an initial observation.
The approach is particularly valuable when investigators need to examine tumors together with the intestinal host environment. Imaging can support studies of mucosal inflammation, immune-cell activity, and changes associated with infectious processes, while also tracking tumor progression or treatment response. This makes it useful for connecting visible disease patterns with interactions among tumors, host defenses, and intestinal conditions.