Peak Nasal Inspiratory Flow
Peak Nasal Inspiratory Flow - Related Videos
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2026
Respiratory muscle weakness is highly prevalent in patients weaning from mechanical ventilation. Resistive inspiratory muscle training (IMT) can improve inspiratory strength and potentially weaning outcomes. This protocol provides a structured approach to offer IMT to selected patients based on the best available knowledge, facilitating its wider application in critical care.
05:50
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2026
This protocol presents Rayleigh breakup as a mild process for aerosolizing non-viral mRNA vectors. Regional deposition for aerosolized mRNA vectors is evaluated by the Alberta Idealized Nasal Inlet (AINI) model. Green fluorescence protein (GFP) expression in human lung cells represents maintenance of physicochemical and biological functions of post-aerosolized mRNA vectors.
10:38
Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface
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Cited by 135 •
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Nasal epithelial cells, obtained through superficial scrape biopsy of human volunteers, are expanded and transferred onto tissue culture inserts. Upon reaching confluency, cells are grown at air liquid interface, yielding cultures of ciliated and non-ciliated cells. Differentiated nasal epithelial cell cultures provide viable experimental models for studying the respiratory mucosa.
09:19
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Cited by 98 •
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We describe here a method for biopsying olfactory mucosa from rat and human nasal cavities. These biopsies can be used for either identifying molecular anomalies in brain diseases or isolating multipotent adult stem cells that can be utilized for cell transplantation in animal models of brain trauma/disease.
05:59
Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
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Cited by 19 •
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The authors present a protocol to collect swine nasal wipes to detect and isolate influenza A viruses.
FAQs
A PNIF reading reflects both nasal airway patency and the person’s respiratory effort. Measurement technique also affects the result, so inconsistent inhalation performance can complicate comparisons. For this reason, changes in airflow should be interpreted alongside how the measurement was performed, rather than treated as a direct measure of mucosal swelling alone.
PNIF provides an objective airflow measurement, but it does not capture every feature of nasal disease. A person’s reported obstruction and clinical examination can add information that the flow value cannot provide by itself. Combining these sources helps researchers characterize nasal congestion more completely, particularly when studying inflammatory or infectious upper-airway conditions.
Repeated measurements allow airflow to be compared across time rather than relying on a single observation. A change in the highest recorded flow may indicate altered nasal patency, including improvement or worsening associated with mucosal swelling or congestion. In immunology and infection studies, this longitudinal approach can help follow disease progression or response to treatment.
The individual uses a handheld nasal flow meter and keeps the mouth closed while inhaling forcefully and rapidly through the nose. The highest recorded airflow is used as the measurement. Because respiratory effort and technique influence the result, the procedure should be performed consistently when readings are compared during a study.
PNIF is useful when investigators need a noninvasive way to quantify nasal obstruction associated with allergic inflammation, rhinitis, or upper respiratory infections. It adds an airflow-based outcome to symptom reports and examination findings. This makes it suitable for tracking nasal airway changes in studies focused on inflammatory or infectious processes.
Researchers can record PNIF repeatedly before and after an intervention to assess whether nasal airflow changes over time. An increase in the highest recorded flow may accompany reduced mucosal swelling or congestion, while a lower value may reflect poorer nasal patency. Interpreting these changes with symptoms and examination findings provides a more complete treatment assessment.