Selective Adhesion
Selective Adhesion - Related Videos
01:14
Adhesion
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2019
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules. Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
07:40
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Cited by 3 •
2016
This flow adhesion assay provides a simple, high impact model of T cell-epithelial cell interactions. A syringe pump is used to generate shear stress, and confocal microscopy captures images for quantification. The goal of these studies is to effectively quantify T cell adhesion using flow conditions.
06:44
Creation of Abdominal Adhesions in Mice
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Cited by 9 •
2016
Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.
03:25
Cytoskeleton and Focal Adhesion Organization Assay: An Immunofluorescence-based Method to Study Cell Adhesion and Spreading on Substrates
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2023
This video describes the technique of studying the cytoskeleton and focal adhesions in primary human colon cancer cells to understand its variations depending on substrate rigidity. This culture of cancer cells on soft and hard substrates allows various downstream biophysical measurements for cancer prognosis.
10:24
Quantitation of Endothelial Cell Adhesiveness In Vitro
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Cited by 10 •
2015
We report an in vitro method that allows the quantitation of the actual number of adhesive cells within an endothelial cell monolayer.
FAQs
Affinity describes the strength of an individual ligand–receptor bond, whereas avidity reflects the combined strength of multiple interactions. Selective adhesion becomes more stable when complementary partners form bonds with sufficient overall strength to resist detachment. This distinction helps explain why attachment may begin through recognition but require several coordinated interactions to remain established under changing physical conditions.
Selectins support the initial rolling of leukocytes along endothelial surfaces, allowing immune cells to sample the vessel wall as they move. Integrins then strengthen adhesion to endothelial cells, producing firmer attachment. Their sequential roles connect molecular recognition with controlled immune-cell positioning and help direct leukocytes toward sites where inflammation is occurring.
Surface charge, hydrophobicity, fluid shear, and receptor activation can all influence adhesion outcomes. These factors affect whether molecular contacts form, remain stable, or fail under physical stress. Considering both molecular compatibility and surface conditions is therefore essential when interpreting why cells, microbes, or biomaterials attach preferentially in one setting but not another.
A useful analysis compares the available ligand–receptor matches with the physical conditions surrounding the attachment interface. Researchers can consider bond affinity and avidity alongside surface charge, hydrophobicity, fluid shear, and receptor activation. This framework distinguishes failures of molecular recognition from failures to maintain contact, clarifying which factor controls initial attachment or continued adhesion.
Pathogens can exploit specific receptors on host cells to establish attachment at preferred cellular sites. That receptor-based interaction may support colonization and can promote subsequent invasion, making adhesion an important step in infection biology. Studying the relevant host–microbe recognition process helps connect surface binding with the progression from contact to infection-related cellular interactions.
Blocking the molecular interactions that support attachment could interfere with leukocyte positioning or pathogen binding to host cells. In infection research, preventing pathogen adhesion offers a way to address colonization and invasion at an early stage. In immunology, understanding adhesion regulation can also clarify how immune-cell trafficking might be altered at sites of inflammation.