Creation of Abdominal Adhesions in Mice

Clement D. Marshall; Michael S. Hu; Tripp Leavitt; Leandra A. Barnes; Alexander T.M. Cheung; Samir Malhotra; H. Peter Lorenz; Michael T. Longaker

doi:10.3791/54450

Journal

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Medicine

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Creation of Abdominal Adhesions in Mice

JoVE Journal
Medicine

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JoVE Journal Medicine

Creation of Abdominal Adhesions in Mice

12,614 Views

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06:44 min

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August 27, 2016

DOI:

10.3791/54450-v

DOI:

10.3791/54450-v

•

06:44 min

August 27, 2016

•

12587 Views

Clement D. Marshall¹, Michael S. Hu¹, Tripp Leavitt¹, Leandra A. Barnes¹, Alexander T.M. Cheung¹, Samir Malhotra¹, H. Peter Lorenz¹, Michael T. Longaker¹

¹Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery,Stanford University School of Medicine

Summary

Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.