Platelet Quality Control
Platelet Quality Control - Related Videos
01:05
Quality Control
0 Views •
2024
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results. Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
06:09
Studying the Protein Quality Control System of D. discoideum Using Temperature-controlled Live Cell Imaging
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2016
The social amoebae Dictyostelium discoideum has recently been established as a system to study protein misfolding and proteostasis. Here, we describe a new imaging-based methodology to study temperature-induced protein aggregation and the cellular stress response in D. discoideum.
09:13
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Cited by 5 •
2017
We describe a straightforward method for the isolation of washed platelets from human blood followed by agonist-induced platelet aggregation measurements by turbidimetry. As an example we apply this method for studying the aggregation response of human platelets to collagen after a pre-incubation with the Pannexin1 channel inhibitor Brilliant Blue FCF.
09:27
DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
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Cited by 10 •
2011
We demonstrate the use of DNA microarrays for expression profiling of the nervous system. We describe RNA quality control, sample labeling, and array hybridization and scanning.
03:58
Purification and Activation of Platelets from Murine Whole Blood
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2025
In this video, we describe a protocol for purifying platelets from murine whole blood and their subsequent activation with the platelet agonist thrombin. When analyzed with flow cytometry, the purified resting platelets are characterized based on the expression of their cell-surface marker CD41, whereas purified activated platelets co-express both the surface markers CD41 and CD62P.
FAQs
Platelet count, volume, pH, morphology or swirling, and selected functional assessments address different aspects of product quality. Considered together, they provide a broader picture than any single result, helping identify changes in platelet concentrates that may arise during collection, processing, or storage and supporting decisions about product suitability before transfusion.
A platelet count alone does not capture every quality attribute. Morphology or swirling provides additional information about the observable condition of the platelets, while functional assessments address their capacity to support hemostasis. Combining these observations with count results helps quality control detect products that may appear adequate numerically but show other concerning changes.
Storage conditions and elapsed time can be evaluated alongside repeated quality measurements to identify trends in platelet concentrates. Monitoring changes in count, volume, pH, morphology or swirling, and other assessments helps distinguish a stable product from one deteriorating during storage. These performance data can then inform handling and storage practices.
A quality-control workflow considers the product from collection through processing and storage. Testing includes the applicable measurements of count, volume, pH, morphology or swirling, and selected functional or sterility assessments, while storage conditions are monitored over time. Results are reviewed before transfusion to identify collection, processing, or storage problems.
Quality-control data are useful whenever platelet products show variation or changes during production and storage. Reviewing performance results can reveal patterns associated with collection, processing, handling, or storage practices. Blood-component services can use those findings to refine product management, support compliance with applicable standards, and improve consistency before products reach patients.
In transfusion medicine, consistent testing helps determine whether platelet concentrates retain the characteristics needed for their intended use. The results support detection of safety or integrity concerns, documentation of performance against blood-component standards, and recognition of products that may provide ineffective transfusion support. This connects laboratory monitoring with safer, more reliable patient care.