Skeletal Maturity
Skeletal Maturity - Related Videos
08:01
Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
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Cited by 15 •
2021
Intact regulation of muscle glucose uptake is important for maintaining whole body glucose homeostasis. This protocol presents assessment of insulin- and contraction-stimulated glucose uptake in isolated and incubated mature skeletal muscle when delineating the impact of various physiological interventions on whole body glucose metabolism.
09:45
Mitochondrial Isolation from Skeletal Muscle
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Cited by 48 •
2011
This protocol describes a procedure to study the respiration of mitochondria isolated from skeletal muscles. This method was adapted from Scorrano et al. (2007). The mitochondrial isolation procedure requires about 2 hours. The mitochondrial respiration can be completed in about 1 hour.
14:36
Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
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Cited by 6 •
2010
The micro-dissected explants technique is a robust and reliable method for isolating proliferative skeletal muscle cells from juvenile, adult or embryonic muscles as a source of skeletal muscle stem cells. Uniquely, these cells have been clonally derived to produce skeletal muscle stem cell lines used for in vivo transplantation.
01:28
Maturation of Endosomes
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2023
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB). Changes in location The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
01:48
Classification of Skeletal Muscle Fibers
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2019
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions. Slow-Twitch Muscle Fibers Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
FAQs
At the growth plates, cartilage follows an organized sequence in which cells proliferate, enlarge, and are replaced by mineralized bone. As this process continues, the plates progressively narrow and eventually close. The resulting structural changes provide the biological basis for estimating maturation and distinguishing ongoing growth from progression toward adult skeletal structure.
Calendar age records time since birth, whereas skeletal maturity reflects biological progression through growth and structural development. These processes do not advance identically in every individual, so two people of the same chronological age may show different degrees of maturation. Using both measures helps clinicians interpret development without treating age in years as a complete description of growth status.
Progressive narrowing indicates that cartilage at the growth plate is being replaced by mineralized bone as maturation advances. Closure represents a later structural stage in that sequence and helps indicate that the bones are approaching adult form. This information is clinically useful because it relates skeletal appearance to developmental stage and helps assess whether substantial growth may remain.
Clinicians commonly estimate it by examining radiographs of the hand and wrist, although other imaging approaches may also be used. The images provide structural evidence of bone development and growth-plate progression, which can then be considered alongside chronological age. This approach supplies a biological measure for evaluating development rather than relying only on the calendar.
The observed stage of bone development can help clinicians judge whether growth is still progressing or has advanced toward completion. Because growth-plate changes accompany maturation, the assessment offers information about remaining growth potential. That information can support developmental evaluation and help place growth-related findings in a biological context when chronological age alone is insufficient.
Clinicians may use the assessment when evaluating growth disorders, developmental status, or conditions requiring coordinated orthopedic and endocrine management. It can also contribute to decisions that depend on understanding growth potential. Its value lies in supplementing other clinical information: skeletal findings provide a biological perspective, while chronological age and the broader medical context remain relevant to interpretation.