Vascular Perfusion Imaging
Vascular Perfusion Imaging - Related Videos
06:05
DiI Perfusion as a Method for Vascular Visualization in Ambystoma mexicanum
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Cited by 3 •
2017
Using a lipophilic 1,1'-Dioctadecy-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) staining technique, Ambystoma mexicanum can undergo vascular perfusion to allow for easy visualization of the vasculature.
10:50
Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
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Cited by 9 •
2013
We show here the in vivo insertion of an osmotic pump for constant local drug delivery and the creation of hindlimb ischemia in a mouse model. Moreover, the hindlimb vasculature is perfused with Microfil, a silicone radiopaque agent, to prepare for micro-computed tomography (micro-CT) imaging.
06:20
Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure
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Cited by 22 •
2011
This is a method to visualise leukocyte adhesion to the endothelium in harvested pressurised vessels. The technique enables studying vascular adhesion under shear flow with differing intraluminal pressures up to 200 mmHg thus mimic-ing the pathophysiological conditions of high blood pressure.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
11:35
Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
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Cited by 16 •
2010
A dual-mode imaging system was developed for non-contact assessment of cutaneous tissue oxygenation and vascular function.
FAQs
Each modality follows a different signal associated with circulation. Contrast agents, radioactive tracers, or ultrasound signals reveal how blood moves through the vascular system and tissues. The resulting measurements can emphasize regional blood volume, transit time, or perfusion distribution, allowing clinicians to examine circulation from complementary perspectives rather than relying on a single indicator.
Blood volume indicates how much blood is present within a region, while transit time reflects how long circulation takes to pass through it. Examining these measurements together helps identify abnormal delivery or movement of blood, including areas that may receive inadequate circulation. This distinction supports more informative assessment than observing vascular anatomy alone.
Microvascular assessment focuses on circulation within small vessels and tissue beds that may not be adequately characterized by examining larger arteries or veins alone. By mapping perfusion in microvascular tissues, the technique can reveal regional differences in tissue supply. This is particularly relevant when organ or tissue viability depends on the quality of local circulation.
Perfusion maps show whether circulation is reduced, uneven, delayed, or otherwise abnormal across an organ or tissue region. Comparing these spatial and timing patterns helps clinicians recognize impaired blood delivery and characterize vascular behavior rather than simply confirming that vessels are present. Such information can support diagnosis and help evaluate the functional significance of a vascular abnormality.
The workflow begins by selecting an imaging approach suited to the circulation being evaluated. The study then tracks an injected contrast agent, radioactive tracer, or ultrasound signal as it passes through arteries, veins, and tissues. Measurements are converted into perfusion information, including blood-flow patterns, blood volume, or transit time, for clinical interpretation.
Its clinical uses include evaluating stroke, peripheral arterial disease, tumors, myocardial ischemia, and organ viability. In these settings, the measurements can reveal regions with impaired or abnormal circulation, help clinicians assess the extent of a problem, and contribute to treatment planning. Repeated studies may also help monitor whether a therapy changes perfusion over time.