Ventricular Apex Resection
Ventricular Apex Resection - Related Videos
03:58
Apical Resection Neonatal Mouse Model: A Surgical Procedure to Amputate the Ventricular Apex to Study Regenerative Potential in a Neonate Mouse Heart
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2025
In this video, we demonstrate the procedure to surgically remove the left ventricular apex of a neonatal mouse heart.
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Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies
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Here, we describe the preparation of viable ventricular slices from adult mice and their use for sharp electrode action potential recordings. These multicellular preparations provide a preserved in vivo like tissue structure, which makes them a valuable model for electrophysiological and pharmacological studies in vitro.
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Brain Tumor Resection in a Mouse Using a Minimally Invasive Resection System
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Source: Alomari, S., et al. Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection. J. Vis. Exp. (2022)This video demonstrates the use of a minimally invasive resection system (MIRS) to excise tumor tissue from an anesthetized mouse implanted with a tumor. The procedure involves securing the mouse onto a stereotactic frame, reopening the previous surgical site to access the brain, and inserting a specialized cannula that utilizes suction and a...
06:08
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
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Cited by 12 •
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A step-by-step video protocol of apical resection is demonstrated in this study. Apical resection is a recently highlighted surgical approach in mammalian heart regeneration research. This study may promote the application of apical resection as a standard methodology in research into the mechanism underlying heart regeneration.
08:49
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FAQs
Reconstructing the ventricular wall is intended to restore a more effective chamber geometry rather than simply leave a tissue defect. A more favorable shape can support ventricular filling and contraction, especially when abnormal apical anatomy has disrupted coordinated motion. The resulting structural correction may improve hemodynamics, meaning blood flow and pressure performance within the heart.
The targeted tissue may be damaged, scarred, aneurysmal, or excessively thickened apical myocardium. These abnormalities can alter the ventricle’s shape or interfere with its ability to fill and contract effectively. Selection therefore focuses on regional structural disease that contributes to impaired function, rather than removing normal apical muscle without a specific anatomical reason.
The procedure can influence both phases by correcting the abnormal geometry of the ventricular apex. Removing diseased or excessive tissue reduces the structural distortion, while reconstruction creates a chamber shape better suited to coordinated movement. This combined approach may help the ventricle fill more effectively and contract with improved regional coordination.
The operation consists of excising the affected portion of apical myocardium and then reconstructing the ventricular wall. The sequence matters because tissue removal addresses the abnormal region, while reconstruction restores chamber integrity and shape. In selected cardiac operations, these steps may be performed together with other repairs directed at associated structural disease.
It may be considered in selected cases involving an apical form of hypertrophic cardiomyopathy or a ventricular aneurysm. In the first setting, excessively thickened apical myocardium is the relevant structural abnormality; in the second, aneurysmal or damaged tissue may distort the chamber. The procedure is therefore tailored to the specific regional anatomy and functional problem.
By treating the diseased apical region and rebuilding the ventricular wall, the operation may improve hemodynamics, reduce symptoms, and support more coordinated ventricular performance. These outcomes reflect correction of a structural contributor to dysfunction rather than treatment of symptoms alone. It may also form one component of a broader cardiac repair when additional abnormalities require surgical attention.