Neurological Conditions

Neurological conditions are disorders that affect the brain, spinal cord, peripheral nerves, or neuromuscular systems, often altering movement, sensation, cognition, or behavior. In pharmacology, treatments act by modifying neuronal signaling, neurotransmitter activity, ion-channel function, inflammation, or other molecular pathways that contribute to disease. Pharmacological management may reduce symptoms, slow disease progression, prevent complications, or support recovery, depending on the condition and therapeutic target. Studying these drug mechanisms helps researchers evaluate treatment efficacy and safety, optimize dosing, and develop therapies for conditions such as epilepsy, Parkinson’s disease, multiple sclerosis, migraine, and neuropathic pain.

Neurological Conditions - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

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Cited by 120 •

2015

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral sclerosis.

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

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Cited by 63 •

2015

This protocol describes how neural progenitor cells can be differentiated from human induced pluripotent stem cells, in order to yield a robust and replicative neural cell population, which may be used to identify the developmental pathways contributing to disease pathogenesis in many neurological disorders.

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram

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Cited by 4 •

2018

The article describes a practical method for recording horizontal eye movements with high accuracy by electro-oculogram in neurological patients, using a cup Ag-AgCl electrode with a wide plastic fringe. Stable measurement requires proper selection and fixation of electrodes, taking sufficient time for light adaptation to occur, and re-calibration as needed.

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