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In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Article DOI: 10.3791/64902-v • 13:17 min • September 29th, 2023
September 29th, 2023 •
*1,2, *2, 2, 1, 1, 1, 2, 2, 3,4, 3, 4, 3, 1,2,4
1Taras Shevchenko National University of Kyiv, 2Bienta/Enamine, 3Karlsruhe Institute of Technology, 4Lumobiotics
* These authors contributed equally

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This protocol presents a set of experiments adopted for the evaluation of photoswitchable anticancer peptides, that can be used in the preclinical screening of such compounds. This includes cytotoxicity assessment in 2D and 3D cell cultures, the evaluation of ex vivo (model tissue) photoisomerization efficiency, and in vivo efficacy.

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In Vitro In Vivo Photocontrolled Biologically Active Compounds Potential Drug Candidates Cancer Photopharmacology Photoswitches Reversible Light-induced Electrocyclic Transformations UV-generated Form Biologically Inactive Form Red Light-generated Form Photoswitchable Drugs Preclinical Research Experiments Animal Care Experimental Procedures Bioethics Commission Bienta Company Buffers Stock Solutions
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