Human Heart Model
Human Heart Model - Related Videos
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Cited by 66 •
2013
Here, we present a systematic approach for developing physiologically relevant, sensitive and specific in vivo assays for interpreting variation in human pathology. Transient genetic manipulation via microinjection of WT and mutant human mRNA and morpholino (MO) antisense oligonucleotides harness the tractability of the developing zebrafish embryo to rapidly assay pathogenic mutations, especially, but not exclusively, in the context of human developmental disorders.
07:59
The Inverted Heart Model for Interstitial Transudate Collection from the Isolated Rat Heart
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2017
This protocol describes a method to collect cardiac interstitial fluid from the isolated, perfused rat heart. To physically separate interstitial transudate from coronary venous effluent perfusate, the Langendorff perfused heart is inverted, and the transudate (interstitial fluid) formed on the cardiac surface is collected using a soft latex cap.
09:45
An Isolated Working Heart System for Large Animal Models
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Cited by 22 •
2014
Most studies involving the Langendorff apparatus use small animal models due to the increased complexity of systems for larger mammals. We describe a Langendorff system for large animal models that allows for use across a range of species, including humans, and relatively easy data acquisition.
06:08
Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
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Cited by 12 •
2016
A step-by-step video protocol of apical resection is demonstrated in this study. Apical resection is a recently highlighted surgical approach in mammalian heart regeneration research. This study may promote the application of apical resection as a standard methodology in research into the mechanism underlying heart regeneration.
12:09
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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Cited by 14 •
2013
A methodology to estimate ventricular fiber orientations from in vivo images of patient heart geometries for personalized modeling is described. Validation of the methodology performed using normal and failing canine hearts demonstrate that that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.
FAQs
A model can represent several cardiac processes together rather than examining each one in isolation. Electrical activation can be linked to muscle contraction, while chamber geometry and tissue mechanics influence how blood moves through the heart. Combining these features helps researchers investigate how a change in one function affects overall cardiac performance under controlled conditions.
The choice depends on which cardiac feature requires investigation and how it will be tested. Computational models support simulations, physical models provide tangible structures or flows, and bioengineered systems can represent engineered tissues or organ-on-a-chip environments. These formats offer different ways to examine structure, function, disease, medical devices, or therapies.
Controlled conditions allow researchers to change selected features while observing their effects on cardiac performance. A model may focus on chamber geometry, electrical activation, contraction, blood flow, or tissue mechanics, making it possible to examine disease-related changes systematically. This approach can clarify disease mechanisms by separating specific factors that may be difficult to isolate in the whole heart.
Because models can reproduce selected structural, functional, or mechanical features of the heart, researchers can use them to examine how particular changes influence performance. This creates a controlled platform for comparing disease effects or testing potential therapies in relation to specific cardiac characteristics. Such work supports the broader goal of developing more personalized approaches to cardiovascular research and treatment.
A study generally begins by identifying the cardiac feature or research question to reproduce, such as chamber geometry, electrical activation, contraction, blood flow, or tissue mechanics. Researchers then select an appropriate model format, establish controlled conditions, introduce the change of interest, and examine its effect on cardiac performance. The resulting observations can guide disease, device, or therapy investigations.
They are useful when researchers need a controlled setting to examine how a device or therapy affects cardiac structure or function before broader evaluation. Depending on the design, the model can represent blood flow, chamber behavior, muscle contraction, electrical activation, or tissue mechanics. These systems support assessment of safety and efficacy while reducing reliance on animal studies.
Engineered tissues and organ-on-a-chip systems provide bioengineered platforms for studying selected features of heart function and disease. They can be incorporated into laboratory testing workflows to examine cardiac responses under controlled conditions. In bioengineering, these approaches complement computational and physical models, helping researchers investigate mechanisms, evaluate therapies or devices, and advance cardiovascular research.