Oncogenesis Research
Oncogenesis Research - Related Videos
11:02
The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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Cited by 111 •
2011
In this report, we describe the three-dimensional skin reconstruct model which mimics human skin in architecture and composition. Melanocyte physiology, melanoma progression and the fate of dermal stem cells have been investigated using the skin reconstruct model. The model is also useful as a preclinical tool for drug assessment.
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cited by 8 •
2014
The protocol reported here allows the evaluation of the efficacy of photodynamic therapy (PDT) in cell lines and the optimization of the PDT settings before applying the therapy in animal models.
10:01
Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
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2026
Here, we present a protocol for the structure-guided design of protein-ligand binding interaction between Sanglifehrin A and Cyclophilin A/Ganoderiol-F, essential in discovering new drugs. The stability of the ligand-receptor complex was evaluated using molecular dynamics simulation.
03:38
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
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Cited by 1 •
2022
The present protocol demonstrates the use of a fast, 3-stage, aptamer-based exponential amplification assay to detect targets. Sample preparation, signal amplification, and color development are covered to implement this system to recognize the presence of theophylline over that of caffeine.
09:14
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
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Cited by 39 •
2011
A modified 3-D in vitro system is presented in which growth characteristics of several tumor cell lines in reconstituted basement membrane correlate with the dormant or proliferative behavior of the tumor cells at a metastatic secondary site in vivo.
FAQs
Genetic alterations can affect genes that regulate proliferation, DNA repair, apoptosis, or signaling, while epigenetic alterations can disrupt how those genes are controlled without changing the underlying DNA sequence. Studying both layers helps researchers explain how normal cellular safeguards are progressively weakened and why altered cells gain advantages that support tumor initiation and continued growth.
Cell-cycle control limits when cells divide, whereas apoptosis removes cells that are damaged or no longer appropriate for survival. Oncogenesis research examines how alterations impair these safeguards, allowing abnormal cells to persist and reproduce. This focus helps connect molecular changes with uncontrolled proliferation and identifies biological processes that may be relevant to cancer treatment or prevention.
Tumors can change as cancer cells acquire additional genetic and epigenetic alterations. Oncogenesis research considers how this evolution may produce populations with different growth, survival, invasion, or treatment-response characteristics. Examining tumor development over time therefore helps explain progression, the emergence of aggressive behavior, and variation in how tumors respond to therapeutic strategies.
Researchers combine molecular, cellular, and genetic approaches to investigate cancer-driving mechanisms. Molecular studies examine altered genes, epigenetic regulation, and signaling pathways; cellular approaches evaluate proliferation, survival, immune-surveillance escape, or invasion; genetic approaches connect specific alterations with tumor-related outcomes. Integrating these levels provides a more complete view than examining any single process alone.
By identifying alterations and cellular mechanisms associated with tumor formation or progression, oncogenesis research can reveal candidate biomarkers. Such markers may help distinguish relevant biological states, support diagnostic development, or provide information about how a tumor is behaving. Their value comes from linking measurable molecular or cellular features with cancer-related processes and outcomes.
Findings from oncogenesis research are useful when a specific cancer-driving mechanism, signaling process, or cellular safeguard becomes a potential intervention point. Researchers can use this mechanistic knowledge to guide targeted therapy development, consider approaches for preventing harmful changes, and investigate why tumors respond differently to treatment. The same work also strengthens biological interpretation of treatment outcomes.