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JoVE Journal

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The Three-Dimensional Human Skin Reconstruct Model

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Article DOI: 10.3791/2937
August 3rd, 2011


Summary August 3rd, 2011

In this report, we describe the three-dimensional skin reconstruct model which mimics human skin in architecture and composition. Melanocyte physiology, melanoma progression and the fate of dermal stem cells have been investigated using the skin reconstruct model. The model is also useful as a preclinical tool for drug assessment.

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