Spiral Arteries
Spiral Arteries - Related Videos
02:35
Culturing Murine Spiral Ganglion Neuron Explants on Multielectrode Arrays
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2025
This video demonstrates the process for isolating spiral ganglion explants from the inner ear and co-culturing them with the organ of Corti on a multielectrode array. Spiral ganglia are carefully extracted and sectioned into smaller tissue sections or explants. These explants are cultured on the multielectrode array's active area to promote neuronal process outgrowth.
03:51
Label-Free Neutrophil Separation from Tracheal Secretion Using Spiral Microfluidics Channel
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2025
This video demonstrates separating neutrophils from tracheal secretions using a microfluidic device with spiral channels. The device achieves efficient separation based on cell size by utilizing varying thicknesses and trapezoidal-shaped channels. The interplay between forces results in large neutrophils accumulating near the inner wall while erythrocytes and mucin aggregates remain near the outer wall, ensuring effective neutrophil separation.
07:51
Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
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Cited by 5 •
2016
We present a protocol to culture primary murine spiral ganglion neuron explants on multi electrode arrays to study neuronal response profiles and optimize stimulation parameters. Such studies aim to improve the neuron-electrode interface of cochlear implants to benefit hearing in patients as well as the energy consumption of the device.
02:40
Analyzing Neural Activity in Primary Murine Spiral Ganglion Neurons Using Multielectrode Arrays
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2025
This video demonstrates the recording of spontaneous and stimulation-dependent neural activity from primary murine spiral ganglion neuron (SGN) cultures on a multielectrode array (MEA). It involves washing and preparing the MEA, recording spontaneous neural activity, and applying controlled electrical stimuli to identify stimulation-dependent neuronal activity.
05:14
Differentiating Immortalized Multipotent Otic Progenitors into Spiral Ganglion Neurons and Evaluating the Differentiation
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2025
The video demonstrates the differentiation of immortalized multipotent otic progenitors (iMOPs) into spiral ganglion neurons (SGNs) and immunofluorescence-based confirmation of the differentiation. The iMOPs are plated onto culture substrate-coated coverslips in a neuronal differentiation medium for differentiation into SGNs. The differentiated cells are labeled with antibodies specific for neuronal differentiation markers and analyzed under a microscope to confirm differentiation.
FAQs
Extravillous trophoblasts invade the muscular walls of these vessels during early gestation. That remodeling widens the arterial channels and reduces their resistance, allowing maternal blood to enter the placental intervillous space more efficiently. The resulting change supports a steadier maternal supply to the placenta rather than maintaining the narrower, more resistant state present before transformation.
The muscular wall is a major structural feature that must be altered for the vessels to widen and become low-resistance channels. This transformation increases the capacity for maternal blood delivery to the placenta, where exchange with the developing embryo occurs. Its importance lies in coordinating vascular structure with the increasing demands of placental development.
Insufficient remodeling can limit placental perfusion because the vessels may not achieve the widened, low-resistance state needed for effective maternal blood delivery. Reduced perfusion can compromise the environment supporting oxygen and nutrient exchange and is associated with pregnancy complications, including preeclampsia and fetal growth restriction.
Remodeled vessels help limit damaging fluctuations in maternal blood flow while still delivering blood into the placental intervillous space. This balance matters because oxygen and nutrient exchange depends on effective placental perfusion, but excessive variation in flow could be harmful. Spiral artery transformation therefore links vascular stability with maternal-fetal support.
Their condition reflects whether the vascular changes needed for effective placental perfusion have occurred. Adequate transformation is consistent with widened, low-resistance channels that support exchange, whereas inadequate remodeling signals impaired placental blood supply. For this reason, spiral arteries provide important biological information about placental development and maternal-fetal health during pregnancy.
These changes illustrate how maternal tissues and placental development are functionally connected. Extravillous trophoblast invasion modifies maternal vessels so they can meet the requirements of the placenta and developing embryo. Studying this relationship helps place pregnancy complications in a biological context: altered vascular remodeling can connect abnormal placental perfusion with preeclampsia or fetal growth restriction.