Facial Nerve Function

Facial nerve function refers to the sensory, motor, and autonomic roles of cranial nerve VII, which are essential for facial expression, communication, taste, and protective reflexes. The nerve carries motor signals to the muscles of facial expression, parasympathetic fibers to the lacrimal and salivary glands, and taste information from the anterior two-thirds of the tongue; it also activates the stapedius muscle to moderate sound. In clinical practice, assessing eye closure, forehead movement, smile symmetry, taste, and tear or saliva production helps localize nerve lesions. These findings support diagnosis and monitoring of conditions such as Bell’s palsy, trauma, tumors, and stroke.

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JoVE EoE - Neuropathology

Performing Crush Axotomy on the Facial Nerve in a Mouse Model

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2025

Source: Olmstead, D. N., et al., Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury. J. Vis. Exp. (2015).This video demonstrates the facial nerve crush procedure in a mouse, where blunt dissection through key landmarks exposes the facial nerve trunk at the stylomastoid foramen. Forceps are then used to compress the nerve trunk, inducing axonal damage and disrupting neuronal signal transmission.

Inducing a Facial Nerve Injury in a Rat Model

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2025

This video demonstrates a surgical protocol on a rat model, detailing steps from anesthesia preparation to facial nerve injury induction. This protocol is useful for studying nerve regeneration and surgical techniques in medical research.

Facial Nerve Axotomy in Mice: A Model to Study Motoneuron Response to Injury

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Cited by 27 •

2015

We present a surgical protocol detailing how to perform a cut or crush axotomy on the facial nerve in the mouse. The facial nerve axotomy can be employed to study the physiological response to nerve injury and test therapeutic techniques.

Subcutaneous Trigeminal Nerve Stimulation to Relieve Neuropathic Facial Pain

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2025

Source: Jakobs, M., et al. Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain. J. Vis. Exp. (2017)This procedure demonstrates the implantation of subcutaneous electrodes for trigeminal nerve stimulation to treat neuropathic facial pain. The electrodes are tunneled subcutaneously from the affected facial region to an infraclavicular pocket, where they are connected to an internal pulse generator (IPG). The IPG delivers electrical stimulation, activating mechanoreceptor...

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

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Cited by 8 •

2017

Treating chronic or neuropathic facial pain can be challenging when medical or standard treatment fails. Subcutaneous nerve field stimulation is the least invasive form of neuromodulation and is used for chronic back pain. We applied this technology to treat chronic and neuropathic trigeminal facial pain.

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