Tissue Destruction
Tissue Destruction - Related Videos
08:24
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
0 Views •
Cited by 19 •
2011
Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.
01:12
Non-destructive Tests for Concrete Strength
0 Views •
2024
The rebound hammer test, also known as the Schmidt hammer test, is a non-destructive technique for evaluating the hardness of concrete and, indirectly, the strength of concrete. It operates on the principle that the rebound of a spring-driven mass from a concrete surface correlates to the surface's hardness. The device comprises a mass within a tubular housing, a spring mechanism, and a plunger that strikes the concrete. Upon release, the energy imparted to the mass by the spring causes it to...
09:24
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
0 Views •
Cited by 2 •
2017
A simple and non-destructive technique that measures the average content of drug substances in formulated drug products containing fluorine using low-field fluorine-19 (19F) time-domain (TD) nuclear magnetic resonance (NMR) is presented here. The technique can be applied to the development and manufacturing of drugs in the pharmaceutical industry.
10:13
Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
0 Views •
Cited by 8 •
2022
The present protocol develops an image-based technique for rapid, non-destructive, and label-free regional cell density and viability measurement within 3D tumor aggregates. Findings revealed a cell-density gradient, with higher cell densities in core regions than outer layers in developing aggregates and predominantly peripheral cell death in HER2+ aggregates treated with Trastuzumab.
07:48
Working with Human Tissues for Translational Cancer Research
0 Views •
Cited by 4 •
2015
Translational cancer research is dependent on extraction of human tissues. Much work has gone into optimizing extraction methods for ex vivo analysis. Here, we describe tissue processing methods allowing for maximal data output from limited samples.
FAQs
Trauma, ischemia, infection, immune reactions, and chemical or thermal injury can initiate different forms of cellular stress, but they may converge on disrupted cell membranes and altered metabolism. These changes can lead to necrosis, an uncontrolled form of cell death, followed by inflammation and removal of damaged material. The initiating cause remains important for clinical management.
The cause helps determine both the likely pattern of injury and the appropriate response. Ischemia, infection, immune reactions, trauma, and chemical or thermal exposure represent different initiating problems, even though they can produce overlapping cellular damage. Identifying that initiating process supports decisions about wound care, infection control, debridement, or targeted tissue ablation.
Necrosis reflects severe cellular injury with loss of viable tissue, while inflammation is a response associated with the damaged area. Together, these processes can extend the clinical consequences beyond the initially injured cells by disrupting local structure and function. Their presence helps explain why clinicians evaluate both the tissue itself and the condition of the affected organ or region.
Clinical impact depends on how much tissue has been damaged, where the injury occurs, and which organ or body region is involved. Loss of cells and extracellular structures can impair local function, while the underlying cause may continue to produce injury. Clinicians therefore assess both the visible or measurable extent of damage and its relationship to organ performance.
Assessment combines physical examination with imaging and laboratory findings. Examination helps characterize the affected region, imaging can help evaluate the extent of structural damage, and laboratory results may provide additional information about the underlying process. Interpreting these findings together helps clinicians distinguish the likely cause and select an intervention suited to the observed injury.
Management is guided by the cause and extent of injury. Wound care supports treatment of affected areas, debridement removes damaged material, infection control addresses an infectious contribution, and targeted tissue ablation is used when deliberately eliminating selected tissue is appropriate. These approaches aim to address the source or consequences of damage rather than relying on one universal intervention.
Targeted tissue ablation may be considered when treatment requires deliberate elimination of a defined area of tissue rather than general wound management. Its use must be guided by clinical assessment, including examination, imaging, and laboratory findings, together with the suspected cause and extent of injury. This approach illustrates how tissue destruction can be therapeutically controlled in selected circumstances.