Mitotic Region

A mitotic region is a localized area of tissue where cells actively undergo mitosis, generating new cells that support growth and developmental patterning. Cells in this region progress through the cell cycle, duplicate their chromosomes, separate sister chromatids during mitosis, and divide through cytokinesis, while regulatory signals coordinate division with cell differentiation. In developmental biology, identifying mitotic regions helps explain how tissues expand, maintain renewing cell populations, and establish organized structures. Analyses of cell division patterns in these regions can clarify processes such as meristem development, embryonic growth, tissue formation, and the effects of genetic or environmental changes on development.

Mitotic Region - Related Videos

Research

JoVE Journal - Developmental Biology

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

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Cited by 8 •

2016

Mitosis is critical to every living organism and defects often lead to cancer and developmental disorders. Using this imaging protocol and zebrafish as a model system, researchers can visualize mitosis in a live vertebrate organism and the multitude of defects that arise when mitotic processes are defective.

Education

JoVE Core - Molecular Biology

The Mitotic Spindle

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2021

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei. The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

The Mitotic Spindle

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2025

The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei. The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...

Research

JoVE Journal - Immunology and Infection
Free Sample

Fluorescent in situ Hybridization on Mitotic Chromosomes of Mosquitoes

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Cited by 45 •

2012

Among the three mosquito genera, namely Anopheles, Aedes, and Culex, physical genome mapping techniques were established only for Anopheles, whose members possess readable polytene chromosomes. For the genera of Aedes and Culex, however, cytogenetic mapping remains challenging because of the poor quality of polytene chromosomes. Here we present a universal protocol for obtaining high-quality preparations of mitotic chromosomes and an optimized FISH protocol for all three genera of mosquitoes.

Research

JoVE Journal - Biology
Free Sample

Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets

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Cited by 19 •

2016

The assembly and positioning of the mitotic spindle depend on the combined forces generated by microtubule dynamics, motor proteins and cross-linkers. Here we present our recently developed methods in which the geometrical confinement of spherical emulsion droplets is used for the bottom-up reconstitution of basic mitotic spindles.

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