Colon Cancer Surgery
Colon Cancer Surgery - Related Videos
05:58
Surgical Trunk Oriented Laparoscopic Right Hemicolectomy (ST-LRH) for Right-Sided Colon Cancer
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2025
This protocol describes Surgical Trunk-oriented Laparoscopic Right Hemicolectomy (ST-LRH), a modified laparoscopic right hemicolectomy designed to optimize vascular management and lymph node dissection, simplify surgical procedures, and improve surgical safety and efficiency.
28:15
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Cited by 22 •
2010
Reduced/absent expression of Pms2 and/or ERCC1 in entire crypts is a frequent event within 10 cm on each side of colonic adenocarcinomas, likely the basis of a field defect with high mutability and progression to cancer. Deficiency in Ku86 or CcOI is much less frequent in these field defects.
13:04
In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
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Cited by 10 •
2015
We outline a protocol that implements both in vivo and ex vivo approaches to study ovarian cancer colonization of peritoneal adipose tissues, particularly the omentum. Furthermore, we present a protocol to quantitate and analyze immune cell-structures in the omentum known as milky spots, which promote metastases of peritoneal adipose.
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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Cited by 111 •
2016
Mice bearing the Colon-26 (C26) carcinoma represent a classical model of cancer cachexia. Progressive muscle wasting occurs in association with tumor growth, over-expression of muscle-specific ubiquitin ligases, and reductions in muscle cross-sectional area. Fat loss is also observed. Cachexia is studied in a time-dependent manner with increasing severity of wasting.
03:18
Modeling Ovarian Cancer Cell Colonization of Omentum: An Ex Vivo Method to Establish Milky Spot Colonization of Fluorescently Labeled Ovarian Cancer Cells in Murine Omentum Explants
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2023
In this video, we establish an ex vivo omental organ culture overlaid with GFP-expressing ovarian cancer cells to study ovarian cancer colonization within the omental explant. This protocol analyzes immune cell structures within the omentum known as milky spots that promote metastases.
FAQs
Removing nearby healthy tissue helps provide adequate margins around the tumor, while regional lymph-node removal supports assessment of whether the cancer has spread beyond the primary site. These two elements serve different purposes: margins relate to the tissue removed around the tumor, whereas lymph nodes provide information for evaluating disease extent and planning further treatment.
During a colectomy, surgeons divide the blood supply associated with the affected bowel segment before removing the specimen. This step is part of isolating the involved section and allows the tumor, nearby tissue, and regional lymph nodes to be removed together. The resulting specimen can then support both disease control and assessment of spread.
After the affected bowel segment is removed, surgeons usually reconnect the remaining bowel through an anastomosis. However, some patients require a temporary or permanent ostomy instead. The provided information indicates that this choice varies among patients, so the final bowel configuration is determined as part of the surgical plan rather than assumed for every colectomy.
Open, laparoscopic, and robotic approaches are alternative ways to perform colon cancer surgery. The approach may be selected according to the tumor's location and stage, the patient's anatomy, and overall health. These factors help guide how surgeons access and remove the affected colon segment, while the operative goal remains removal of the tumor with appropriate surrounding tissue and nodes.
The operative sequence includes isolating the affected colon segment, dividing its blood supply and bowel, and removing the specimen with adequate margins. Surgeons then usually reconnect the bowel through an anastomosis, although an ostomy may be required for some patients. This workflow combines tumor removal with collection of tissue needed to assess regional disease.
For localized colon cancer, surgery can provide definitive treatment by removing the tumor and evaluating regional lymph nodes. When disease is advanced, surgery may be combined with chemotherapy or other therapies. Thus, the operation has both a treatment role and a staging-related role, while the broader treatment plan depends on whether disease remains localized or has progressed.