Embryo Migration

Embryo migration is the movement of a developing embryo through the reproductive tract to the uterine cavity, a critical step before implantation and pregnancy. After fertilization, coordinated contractions of smooth muscle and directional activity of ciliated epithelial cells transport the embryo through the fallopian tube while it undergoes early cell divisions. In medicine, understanding this process helps researchers investigate implantation, infertility, and ectopic pregnancy, in which an embryo implants outside the uterus. It also informs assisted reproductive technologies, including embryo transfer, by clarifying how timing, transport, and uterine readiness influence reproductive outcomes.

Embryo Migration - Related Videos

Research

JoVE Journal - Developmental Biology

Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos

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Cited by 4 •

2016

Combining cell transplantation, cytoskeletal labeling and loss/gain of function approaches, this protocol describes how the migrating zebrafish prospective prechordal plate can be used to analyze the function of a candidate gene in in vivo cell migration.

Visualizing Neural Crest Cell Migration in a Zebrafish Embryo Using Multi-Photon Time Lapse Imaging

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2025

Source: Williams, A. L., et al. Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos. J. Vis. Exp. (2017)This video showcases a multi-photon time-lapse imaging protocol to visualize the migration of neural crest cells in a zebrafish embryo in real-time with high resolution.

Multi-Photon Time Lapse Imaging to Visualize Development in Real-time: Visualization of Migrating Neural Crest Cells in Zebrafish Embryos

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Cited by 7 •

2017

A combination of the advanced optical techniques of laser scanning microscopy with long wavelength multi-photon fluorescence excitation was implemented to capture high-resolution, three-dimensional, real-time imaging of neural crest migration in Tg(sox10:EGFP) and Tg(foxd3:GFP) zebrafish embryos.

Education

JoVE Science Education - Advanced Biology

The Transwell Migration Assay

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2023

Cells migration in response to chemical cues is crucial to development, immunity and disease states such as cancer. To quantify cell migration, a simple assay was developed in 1961 by Dr. Stephen Boyden, which is now known as the transwell migration assay or Boyden chamber assay. This set-up consists an insert which separates the wells of a multiwell plate into top and bottom compartments. Cells whose migration is to be studied are seeded into the top compartment and the chemoattractant...

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations

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Cited by 28 •

2010

Drosophila hemocytes disperse over the entirety of the developing embryo. This protocol demonstrates how to mount and image these migrations using embryos with fluorescently labelled hemocytes.

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