Fetal Alcohol Syndrome
Fetal Alcohol Syndrome - Related Videos
10:07
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
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Cited by 34 •
2012
In order to understand the molecular mechanisms of the ethanol-induced developmental damage, we have developed a zebrafish model of ethanol exposure and are exploring the physical, cellular, and genetic alterations that occur after ethanol exposure1. We then seek to find potential interventions and rapidly test them in this animal model.
19:57
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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Cited by 4 •
2017
Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical settings.
12:19
Identifying Alcohols - Student Protocol
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2020
Source: Lara Al Hariri and Ahmed Basabrain at the University of Massachusetts Amherst, MA, USA Ferric Chloride Test for PhenolsExpand In this lab, you will identify an unknown alcohol using the ferric chloride test, the Jones test, and the Lucas test. You'll test known alcohols alongside the unknown alcohol as examples of positive and negative results for each test. The four known alcohols are 1-butanol, a primary alcohol, 2-butanol, a secondary alcohol, 2-methyl-2-propanol, a tertiary...
03:32
Identifying Alcohols - Concepts
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2020
Alcohols Alcohols are organic compounds that are amongst the most recognizable and familiar, as they have wide-ranging applications and uses in everyday life. Alcohols are organic molecules containing a hydroxyl functional group connected to an alkyl or aryl group (ROH). If the hydroxyl carbon only has a single R group, it is known as primary alcohol. If it has two R groups, it is a secondary alcohol, and if it has three R groups, it is a tertiary alcohol. Like many other organic compounds,...
09:39
Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
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Cited by 3 •
2021
This protocol describes the generation of integration free iPSCs from fetal tissue fibroblasts through delivery of episomal plasmids by nucleofection followed by description of methods used for iPSC characterization and neuronal differentiation.
FAQs
Alcohol can reach the developing fetus by crossing the placenta, giving prenatal exposure access to developing tissues. Its effects can interfere with cell growth, migration, and differentiation, the processes by which cells multiply, move, and acquire specialized functions. This helps explain why FAS may involve physical development as well as later brain-related and behavioral consequences.
The timing and amount of prenatal alcohol exposure influence the pattern of abnormalities, rather than producing an identical outcome in every pregnancy. Exposure during different stages may affect tissues undergoing different developmental processes, while the amount can also shape the resulting pattern. Clinically, this variability makes it important to consider each child’s physical, developmental, and behavioral findings individually.
Cellular disruption is central to the medical significance of FAS. Alcohol-related interference with growth can affect how much tissue develops; altered migration can prevent cells from reaching appropriate locations; and disrupted differentiation can change the specialized roles cells acquire. Together, these mechanisms connect prenatal exposure with abnormalities that may span growth, facial development, brain function, and behavior.
Assessment should integrate physical and neurobehavioral information rather than focus on a single sign. Clinicians consider growth impairment and distinctive facial features alongside developmental and behavioral effects associated with altered brain development. This combined view supports recognition of the condition and helps identify the individual’s needs for educational, behavioral, and clinical support.
Care is guided by the person’s developmental and neurobehavioral profile. Educational support can address developmental needs, behavioral interventions can respond to behavioral difficulties, and clinical interventions can target other identified concerns. Because FAS can affect people in different ways, combining these supports with assessment findings allows care to be tailored rather than applying one uniform plan.
Prevention centers on avoiding alcohol exposure before and during pregnancy. Medical counseling should communicate this clearly and without blame, both before pregnancy and once pregnancy begins. A nonjudgmental approach supports clear discussion of prevention while reinforcing that avoiding prenatal alcohol exposure is the central preventive measure for FAS.