Mouse Urogenital System
Mouse Urogenital System - Related Videos
03:24
Extracting Prostate from Mouse Urogenital System: A Technique to Separate Prostate Gland from Other Urinary and Genital System Organs in Male Mouse
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2023
In this video, we describe the procedure for the dissection of the urogenital system or UGS from a male mouse model. This UGS is further dissected ex vivo to isolate the prostate gland and study its role in prostate cancer development.
10:24
A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract
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Cited by 49 •
2011
Here, we describe an efficient high throughput in situ hybridization (ISH) method for visualizing patterns of mRNA expression in developing fetal mouse prostate tissue sections. The method can be easily adapted to visualize mRNA expression patterns in other mouse tissues or in tissues from other species.
08:44
Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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Cited by 10 •
2013
To unravel the earliest molecular mechanisms underlying prostate cancer initiation, novel and innovative human model systems and approaches are desperately needed. The potential of pre-prostatic urogenital sinus mesenchyme (UGSM) to induce pluripotent stem cell populations to form human prostate epithelium is a powerful experimental tool in prostate research.
01:28
Microbiota of the Urogenital Tract
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2026
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
09:08
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Cited by 59 •
2011
Magnetic resonance imaging (MRI) has become an increasingly popular tool for examining the phenotype of genetically altered mice. This article illustrates the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI.
FAQs
Glomeruli first filter blood, producing a filtrate that enters the renal tubules. Tubular segments then modify that filtrate before urine reaches the ureters. This division allows the kidneys to adjust the final urinary product rather than simply remove fluid, making these structures important for investigating how altered filtration or tubular processing may contribute to urinary tract disorders.
The ability to concentrate urine reflects how effectively the kidney modifies filtrate during passage through the renal tubules. Changes in this function can indicate disrupted renal processing even when the initial filtration step is not the primary focus. Consequently, concentration behavior provides a useful physiological outcome when studying kidney development, disease mechanisms, or drug effects.
The urinary and reproductive systems are linked by shared developmental pathways and anatomical connections. This relationship means that a developmental change affecting one part of the urogenital system may have implications for another, including reproductive structures or urinary tract organization. Mouse studies therefore help examine congenital anomalies that cannot be understood by considering either system in isolation.
The reproductive tract does more than produce gametes; it also supports their transport through connected reproductive structures. Examining both production and movement helps researchers study reproductive biology as a coordinated process. In mice, this framework can be applied to questions about how anatomical organization and tract function influence reproductive outcomes.
Mice provide conserved urogenital anatomy and physiology, allowing researchers to examine processes relevant to human medicine. Their systems can support studies of kidney development, urinary tract disorders, reproductive biology, and congenital anomalies. They are also used to assess drug effects, generating disease-mechanism and response data that can inform diagnostic or therapeutic strategy development.
A mouse model can connect anatomical findings with functional questions involving filtration, tubular modification, urine concentration, reproductive transport, or developmental organization. It may also reveal how a disorder arises or how a drug affects the system. These outcomes support broader medical research by linking experimental observations to disease mechanisms and potential diagnostic or therapeutic approaches.