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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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JoVE Journal Medicine
Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells

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13,527 Views

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08:44 min

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June 22, 2013

DOI:

10.3791/50327-v

DOI:
10.3791/50327-v

•

08:44 min
June 22, 2013

•

5 Views
, ,
1Department of Surgery, Section of Urology,University of Chicago, 2Committee on Cancer Biology,University of Chicago

Summary

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To unravel the earliest molecular mechanisms underlying prostate cancer initiation, novel and innovative human model systems and approaches are desperately needed. The potential of pre-prostatic urogenital sinus mesenchyme (UGSM) to induce pluripotent stem cell populations to form human prostate epithelium is a powerful experimental tool in prostate research.

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Cai, Y., Kregel, S., Vander Griend, D. J. Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells. J. Vis. Exp. (76), e50327, doi:10.3791/50327 (2013).

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