Paraplegia Model
Paraplegia Model - Related Videos
05:59
Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
0 Views •
Cited by 8 •
2014
The lack of mechanistic understanding of spinal cord ischemia-reperfusion injury has hindered further adjuncts to prevent paraplegia following high risk aortic operations. Thus, the development of animal models is imperative. This manuscript demonstrates reproducible lower extremity paralysis following thoracic aortic occlusion in a murine model.
07:32
Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia
0 Views •
Cited by 17 •
2020
Impaired mitochondrial transport and morphology are involved in various neurodegenerative diseases. The presented protocol uses induced pluripotent stem cell-derived forebrain neurons to assess mitochondrial transport and morphology in hereditary spastic paraplegia. This protocol allows characterization of mitochondrial trafficking along axons and analysis of their morphology, which will facilitate the study of neurodegenerative disease.
06:30
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
0 Views •
Cited by 119 •
2015
We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
0 Views •
Cited by 66 •
2013
Here, we present a systematic approach for developing physiologically relevant, sensitive and specific in vivo assays for interpreting variation in human pathology. Transient genetic manipulation via microinjection of WT and mutant human mRNA and morpholino (MO) antisense oligonucleotides harness the tractability of the developing zebrafish embryo to rapidly assay pathogenic mutations, especially, but not exclusively, in the context of human developmental disorders.
02:00
Molecular Models
0 Views •
2020
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules. Skeletal Model Simpler two-dimensional representations of chemical compounds are accomplished using skeletal models. The illustration shows only the molecular framework or bonds without explicitly showing the atoms. In this representation, many of the carbon atoms...
FAQs
Spinal cord damage can interrupt descending motor and sensory pathways that normally carry signals between the brain and the lower body. This disruption limits motor control and sensory communication below the injury, creating measurable neurological and functional consequences. Examining these changes helps researchers connect tissue injury with loss of movement, altered sensation, and other effects relevant to spinal cord pathology.
The consequences of spinal cord injury may extend beyond voluntary movement because autonomic function can also change. Including autonomic effects gives a broader physiological picture of injury than motor testing alone. In a paraplegia model, this perspective helps researchers evaluate whether an intervention influences the wider consequences of disrupted central nervous system communication, rather than focusing only on lower-limb performance.
Neuroplasticity and neural repair represent complementary research directions after spinal cord injury. Neuroplasticity concerns changes that may support altered nervous-system function, whereas neural repair focuses on restoring damaged neural structures or pathways. Models of paraplegia provide a controlled setting for investigating both possibilities and for determining whether experimental treatments produce meaningful neurological, physiological, or functional improvement.
A paraplegia model provides a controlled framework for evaluating interventions before clinical translation. Researchers can use it to investigate pharmacological treatments, cell-based therapies, electrical stimulation, and assistive technologies in relation to injury-associated outcomes. The model supports comparison of whether an approach addresses spinal cord pathology, promotes functional recovery, or helps compensate for disrupted communication between the brain and lower body.
Studies can examine neurological, physiological, and functional consequences of spinal cord injury within the same experimental framework. These domains capture different aspects of the condition: nervous-system disruption, changes in body function, and effects on performance or capability. Considering them together helps researchers determine whether an intervention produces broad benefit or improves only one aspect of the injury response.
In medicine, the model links investigation of spinal cord pathology with rehabilitation, neural repair, and assistive technology development. Its controlled experimental setting allows candidate interventions to be studied before they are considered for clinical translation. This makes it useful for connecting mechanistic research with practical strategies intended to address impaired function after central nervous system injury.