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JoVE Journal Neuroscience
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
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Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Article DOI: 10.3791/52741-v • 06:30 min • June 13th, 2015
June 13th, 2015 •
1, 1, 1, 1, 1, 1, 1, 2, 1
1Department of Pediatrics, University of Alberta, 2Montreal Neurological Institute and Hospital, McGill University

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We present an optimized inexpensive and reliable negative geotaxis assay in Drosophila melanogaster as a model for neurodegenerative disorders. Being more sensitive to mild locomotor defects, this assay will help screen for potential genetic interactions and drug targets.

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Quantitative Analysis Climbing Defects Drosophila Model Neurodegenerative Disorders Locomotive Defects Therapeutic Treatment Strategies Whole Exome Sequencing Genes Locomotive Functioning Reliable Assay Model Organisms Novel Targets Therapeutic Interest Negative Geotaxis Assay Glass Graduated Cylinder Wax Barrier Film Threshold Distance Experiment Duration Sensitivity Mild Mobility Dysfunctions Cost Effective Highly Reproducible Results Screening Candidate Drugs Drosophila Mutants
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