Posterior Cingulate Cortex
Posterior Cingulate Cortex - Related Videos
03:11
Generation of Medial Thalamus-Anterior Cingulate Cortex Slices from Mouse Brains
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2025
The video demonstrates the preparation of medial thalamus-anterior cingulate cortex (MT-ACC) slices from mouse brains. A mouse's brain is dissected, cuts are made to expose the MT-ACC pathway, and slices are generated using a vibratome. The MT-ACC slices are then maintained in oxygenated artificial cerebrospinal fluid.
09:00
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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Cited by 3 •
2015
Stereotactic Electroencephalography (SEEG) is an operative technique used in epilepsy surgery to help localize seizure foci. It also affords a unique opportunity to investigate brain function. Here we describe how SEEG can be used to investigate cognitive processes in human subjects.
04:18
Monitoring the Brain Cortex with a Multi-Electrode Array in Response to Seizure-Inducing Agents
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2025
In this video, the effects of transcranial direct-current stimulation (tDCS) on brain slices containing the anterior cingulate cortex (ACC) and thalamus regions are investigated, using a multi-electrode array (MEA) to measure electric signals. By delivering electric pulses and infusing seizure-inducing drugs, the study investigates the ACC response to seizures.
03:59
Implantation of Electrodes into a Mouse Cortex for Electrocorticographic Recordings
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2025
This video demonstrates a protocol for implanting electrocorticographic electrodes in the mouse cerebral cortex to record electrical signals in response to adeno-associated viruses that target and manipulate cofilin expression.
06:42
Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
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Cited by 3 •
2018
Threats reliably evoke shifts in high-level ideological investment, but little work to date has explored the neural mechanisms underlying these dynamics. This paper describes how continuous theta burst transcranial magnetic stimulation may be employed to test the contribution of the posterior medial frontal cortex (and/or other regions) to threat-related ideological shifts.
FAQs
The PCC operates as part of a distributed circuit rather than as an isolated memory center. Its connections with the hippocampus, medial prefrontal cortex, and association areas allow information from memory-related and higher-order systems to be integrated. This network architecture helps explain how contextual evaluation and internally directed cognition can occur together during the same mental activity.
By linking contextual information with autobiographical memory retrieval, the PCC can help determine how a remembered event relates to the current mental context. This function is relevant when interpreting symptoms involving memory or self-related thought, because altered performance may reflect disrupted integration across connected networks rather than a single isolated cognitive process.
Attention shifts between internal and external focus depend partly on PCC interactions with broader association networks. When internally directed cognition dominates, the region’s connectivity provides a framework for self-referential processing and memory-related activity. Studying these shifts helps clinicians and researchers relate PCC function to changes in attention and internally focused thought.
Lesion studies provide a complementary perspective to activity measurements: they examine what cognitive or clinical changes follow damage involving the PCC or its connected systems. Functional imaging shows patterns of activity or connectivity, whereas lesion evidence helps relate disrupted tissue to observed symptoms. Using both approaches strengthens interpretation of PCC-related findings in medicine.
In Alzheimer’s disease, PCC activity and connectivity are investigated as potential indicators of disease-related network changes. The medical value lies not only in observing a signal, but also in evaluating whether PCC measures track disease status over time. Such research may support biomarkers for diagnosis and disease monitoring, as well as treatment development.
Studies of the PCC generally combine functional imaging with lesion-based evidence and clinical interpretation. Researchers examine PCC activity or connectivity, assess how lesions relate to cognitive or neurological changes, and compare those observations with the condition under investigation. This approach connects brain-network findings to symptoms in Alzheimer’s disease, depression, epilepsy, or disorders of consciousness.
Connectivity is valuable because it captures relationships between the PCC and other brain regions, not simply activity within one location. In medicine, those patterns can be evaluated as candidate biomarkers, meaning measurable features that may assist diagnosis, disease monitoring, or treatment development. Interpretation still depends on linking the pattern to clinical findings and the disorder studied.