Tail Volume Measurement
Tail Volume Measurement - Related Videos
08:54
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Cited by 175 •
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The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system measures the blood pressure in up to 8 mice or rats simultaneously. This tail-cuff system uses Volume Pressure Recording (VPR) to measure the blood pressure by determining the tail blood volume.
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Solutions are utilized to some degree in almost all biological research applications. Therefore understanding how to measure and manipulate them is imperative to any experiment. In this video, concepts in preparing solutions are introduced. Solutions consist of a solute dissolved in solvent to yield a homogeneous mixture of molecular substances. Solutions are generally identified by their components and corresponding concentrations. Concentrated solutions are diluted through various...
09:15
Measuring Pressure Volume Loops in the Mouse
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Cited by 16 •
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This manuscript describes a detailed protocol for the collection of pressure-volume data from the mouse.
10:17
The Tail Suspension Test
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Cited by 534 •
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The tail-suspension test is validated as an experimental procedure to assess antidepressant efficacy of drug treatments in mice. Mice are suspended by their tails for six minutes and escape-related behaviors are assessed. We describe procedures used in conducting the tail suspension test.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
0 Views •
Cited by 47 •
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Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
FAQs
Plethysmographic tail volume measurement translates a physical or electrical signal into a quantitative volume value. With water-based measurement, displacement in the chamber reflects the space occupied by the tail; electrical approaches instead detect changes in electrical properties. The resulting numerical readings make swelling or vascular alterations easier to compare than visual inspection alone, especially across repeated observations.
Tracking readings over time reveals whether tail volume increases, remains stable, or changes after an intervention. This temporal comparison is important because the method is used to evaluate evolving swelling, edema, vascular changes, and treatment responses. Repeated measurements therefore provide a stronger basis for judging experimental outcomes than relying on a single observation.
A measured change can provide an objective indicator of swelling, edema, or vascular alteration in the animal model. These changes may be difficult to assess accurately by visual inspection alone, so numerical volume data help researchers evaluate disease-related responses. Interpreting the measurement within the study allows comparisons of inflammation, vascular permeability, hypertension, thrombosis, or treatment effects.
The tail is placed in a measurement chamber, where the system detects either water displacement or a change in electrical properties. That signal is converted into a volume reading for quantitative analysis. Researchers can then repeat the measurement at relevant points in the experiment, allowing the resulting values to be compared over time.
Researchers use this approach when an experiment requires quantitative monitoring of tail swelling or vascular responses. Supported applications include studies of inflammation, vascular permeability, hypertension, thrombosis, and drug responses. Because the method produces numerical measurements, it can help evaluate disease mechanisms, assess treatment efficacy, and document changes that may not be readily apparent from observation alone.
Repeated volume readings provide an objective way to compare tail changes during a treatment study. If the experimental condition or drug alters swelling, edema, or vascular behavior, those effects can be followed numerically over time. This supports assessment of treatment efficacy and gives researchers measurable experimental outcomes rather than depending only on visual judgments.