Targeted Muscle Reinnervation
Targeted Muscle Reinnervation - Related Videos
07:00
Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
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2025
This protocol presents a reproducible rat model using sensory nerves to mimic human neuroma pain and assess surgical treatments, offering a valuable tool for translational neuroma research.
06:49
Rat Hindlimb Below-Knee Amputation Model and Immediate Targeted Muscle Reinnervation
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2026
This protocol demonstrates how to perform a below-knee amputation in rats and to immediately perform targeted muscle reinnervation (iTMR) to investigate strategies to treat and prevent amputation-related pain and to better understand pain mechanisms associated with amputation.
03:26
Targeted Muscle Reinnervation: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
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Cited by 5 •
2024
The protocol outlines the surgical procedure for the treatment of postamputation pain using Targeted Muscle Reinnervation (TMR). TMR will be compared with two other surgical techniques, specifically Regenerative Peripheral Nerve Interface (RPNI) and neuroma excision, followed by immediate burying within muscle under the context of an international, randomized controlled trial.
09:24
Molecular Imaging to Target Transplanted Muscle Progenitor Cells
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Cited by 3 •
2013
A non-invasive means to evaluate the success of myoblast transplantation is described. The method takes advantage of a unified fusion reporter gene composed of genes whose expression can be imaged with different imaging modalities. Here, we make use of a fluc reporter gene sequence to target cells via bioluminescence imaging.
07:29
Paired Patch Clamp Recordings from Motor-neuron and Target Skeletal Muscle in Zebrafish
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Cited by 17 •
2010
Larval zebrafish represent the first vertebrate model system to allow simultaneous patch clamp recording from a spinal motor-neuron and target skeletal muscle. This video demonstrates the microscopic methods used to identify a segmental CaP motor-neuron and target muscle cells as well as the methodologies for recording from each cell type.
FAQs
Rerouting creates separate muscle activity patterns for different intended movements. After nerve coaptation, an attempted movement of the missing limb activates the selected muscle supplied by that nerve. The resulting electrical activity can be detected by prosthetic sensors, helping distinguish commands and support more intuitive control of multifunction prostheses.
Selected muscles serve as destinations for transected nerves while providing usable signals for prosthetic control. Their contractions become measurable electrical outputs when the patient attempts movement. This arrangement gives the prosthesis distinct biological inputs and supports control strategies that can separate several intended movements.
Beyond prosthetic control, Targeted Muscle Reinnervation can be used to prevent or treat pain associated with amputation. Coapting a transected nerve to a motor nerve branch and its muscle reroutes the nerve into a new functional pathway. In rehabilitation, this pain-focused role complements the technique’s generation of prosthetic control signals.
The procedure begins with residual peripheral nerves that were transected by amputation. Surgeons identify suitable alternative muscles and the motor nerve branches supplying them, then coapt the transected nerves to those branches. The selected muscles subsequently provide contractions and electrical activity that can be used for prosthetic control.
When a patient attempts to move the missing limb, the reinnervated target muscles contract even though the intended limb segment is absent. Sensors detect the resulting electrical activity and associate distinct patterns with movement commands. This signal pathway can make prosthetic operation more intuitive and improve separation between commands for multifunction devices.
Targeted Muscle Reinnervation is relevant when rehabilitation must address both prosthetic function and post-amputation pain. Its signals can support more natural control of a multifunction prosthesis, while the nerve rerouting strategy can contribute to efforts to prevent or treat neuroma-related and phantom limb pain. Thus, the technique connects surgery with longer-term rehabilitation goals.