Adjacent Segment Disease

Adjacent segment disease is a spinal condition in which motion segments next to a previously fused or surgically stabilized region develop new degeneration and related neurological symptoms. By eliminating movement at one level, fusion can alter spinal biomechanics and increase motion, loading, and stress in neighboring discs and facet joints, potentially contributing to disc degeneration, spinal stenosis, or instability. Patients may experience back or neck pain, radiculopathy, or myelopathy, depending on the affected region and neural structures involved. Neuroscience research and clinical evaluation use neurological examination and imaging to distinguish adjacent segment disease from expected postoperative changes and guide conservative care or additional surgery.

Adjacent Segment Disease - Related Videos

Research

JoVE Journal - Neuroscience
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Transforaminal Full-Endoscopic Lumbar Foraminotomy Under Local Anesthesia for L5/S1 Adjacent Segment Foraminal Stenosis

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Cited by 1 •

2025

This protocol provides a step-by-step guide for performing transforaminal full-endoscopic foraminotomy under local anesthesia. This motion-preserving technique is presented as a minimally invasive surgical alternative to fusion extension for treating L5/S1 foraminal stenosis in patients with adjacent segment disease.

Research

JoVE Journal - Biology

Laparoscopic Left Liver Sectoriectomy of Caroli's Disease Limited to Segment II and III

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Cited by 5 •

2009

This video presents a case of laparoscopic left liver sectoriectomy perfomed in a 53 year old man suffering from Caroli's disease limited to segment II and III of the liver.

Research

JoVE Journal - Biology
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Automated Joint Space Detection Improves Bone Segmentation Accuracy

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2025

The development of an automated joint space detection workflow enabled high-throughput segmentation of distinct murine hindpaw bones with >98% accuracy in wild-type animals. Flexible application to forepaws and paws with inflammatory-erosive arthritis was achieved, but with deprecated performance that warrants further optimization in future studies using publicly available data.

Research

JoVE Journal - Biology
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Volume Segmentation and Analysis of Biological Materials Using SuRVoS (Super-region Volume Segmentation) Workbench

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Cited by 10 •

2017

Segmentation of three-dimensional data from many imaging techniques is a major bottleneck in analysis of complex biological systems. Here, we describe the use of SuRVoS Workbench to semi-automatically segment volumetric data at various length-scales using example datasets from cryo-electron tomography, cryo soft X-ray tomography, and phase contrast X-ray tomography techniques.

Anterior Eye Segment Dissection: A Method to Isolate Cornea Bearing Anterior Segment from Porcine Eye

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2025

In this video, we demonstrate the dissection of the cornea-bearing anterior segment of the porcine eye. The isolated segment can be used for organ culturing to study the pathophysiology of eye disorders.

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