Axon Schwann Interaction
Axon Schwann Interaction - Related Videos
03:58
Schwann Cell-Seeded Conduits for Axonal Regeneration After Spinal Cord Injury
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2025
Source: Lee, Y., et.al. Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap. J. Vis. Exp. (2017)This video demonstrates the use of a piezoelectric polymer conduit seeded with Schwann cells to promote axon regeneration in a transected rat spinal cord. The conduit provides structural guidance, while its bioelectric properties stimulate neurite outgrowth. Schwann cells within the conduit secrete...
09:46
Analyzing Murine Schwann Cell Development Along Growing Axons
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Cited by 1 •
2012
Here we describe a Schwann cell (SC) migration assay in which SCs are able to develop along extending axons.
08:05
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
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Cited by 10 •
2017
This article describes a technique to insert a hollow conduit between the spinal cord stumps after complete transection and fill with Schwann cells (SCs) and injectable basement membrane matrix in order to bridge and promote axon regeneration across the gap.
10:17
Analysis of Schwann-astrocyte Interactions Using In Vitro Assays
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Cited by 6 •
2011
This article intends to describe in stepwise fashion the commonly used in vitro assays used in studying Schwann cell-asrtocyte interactions.
04:25
Isolation of DRG Neurons and Coculture with Schwann Cell Precursors to Generate Schwann Cells
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2025
This video demonstrates a procedure for isolating dorsal root ganglion (DRG) neurons from rat embryos and co-culturing them with Schwann cell precursors to generate mature Schwann cells. The isolated DRGs are processed to isolate neurons and glial cells. The isolated cells are cultured to purify the neurons, which are then co-cultured with Schwann cell-like cells (SCLCs) in a co-culture medium. Interaction with the DRG neurons leads to the maturation of SCLCs into Schwann cells.
FAQs
Axonal neuregulin-1 type III activates ErbB receptors on Schwann cells, linking signals from the axon to Schwann-cell survival, differentiation, and myelin formation. This pathway helps coordinate the maturation of the glial partner with the developmental state of the peripheral axon. Studying it provides a mechanistic framework for understanding how peripheral nerve insulation is established.
Metabolic and trophic support from Schwann cells helps maintain axon survival, while the axon supplies signals that influence Schwann-cell state. This two-way exchange connects cellular maintenance with functional signaling rather than treating myelin as an isolated structure. Consequently, research can evaluate both partners when investigating how peripheral nerves remain viable and organized.
After injury, Schwann cells shift from their developmental role in myelin formation toward clearing damaged myelin, organizing regenerative pathways, and guiding regrowing axons. This change is important because the same cellular partnership must support repair under altered conditions. Comparing these stages helps distinguish mechanisms that establish peripheral nerve function from those that promote recovery after damage.
Research can use this interaction as a framework for examining Schwann-cell differentiation and myelin formation in demyelinating disorders. The neuregulin-1 type III and ErbB connection identifies a specific signaling context, while the axon-support functions broaden the analysis beyond insulation alone. This helps relate cellular communication to peripheral nerve function.
Studies of injured nerves can examine how Schwann cells remove damaged myelin, organize regenerative pathways, and guide regrowing axons. These observations identify cellular events associated with repair and provide context for functional recovery. They also give nerve-repair research a way to connect Schwann-cell behavior with the progress of axonal regrowth.
Strategies aimed at improving recovery can consider more than axon regrowth alone. The relevant biology includes Schwann-cell guidance of regenerating axons, removal of damaged myelin, and continued metabolic and trophic support. Addressing these coordinated functions may help research evaluate repair in relation to the eventual restoration of peripheral nerve function.