Neurologically Intact Impaired

Neurologically intact impaired describes a person who appears neurologically normal on a routine examination but nevertheless has measurable deficits in cognition, sensation, movement, or behavior. This distinction reflects the limits of standard assessments, which may not detect subtle changes in neural network connectivity, synaptic signaling, information processing, or task-specific performance. In neuroscience, the concept helps researchers and clinicians separate preserved basic function from higher-order impairment after conditions such as mild brain injury, early neurological disease, or developmental disruption. Sensitive neuropsychological tests, functional imaging, electrophysiology, and controlled behavioral tasks can reveal these hidden abnormalities, improving diagnosis, outcome measurement, rehabilitation planning, and evaluation of treatment effects.

Neurologically Intact Impaired - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Education

JoVE Science Education - Psychology

Thinking Too Much Impairs Decision-Making

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2023

Source: Peter Mende-Siedlecki & Jay Van Bavel—New York University When we are considering a tough choice between two or more attractive options, we often end up actively weighing the pros and cons of each alternative. By reflecting on their advantages and disadvantages, we attempt to fit a complex, subjective decision into an orderly set of criteria. However, research in psychology suggests that this sort of introspective approach might not always yield the most optimal outcomes.1 In other...

An Automated System for Sound Localization Testing in Hearing-Impaired Listeners

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2026

This protocol introduces an automated sound localization testing system with precise loudspeaker placement and integrated response analysis, validated in normal-hearing participants and participants with single-sided deafness. It provides a reproducible method to assess spatial hearing and supports functional classification using the International Classification of Functioning, Disability and Health (ICF) framework.

Electrophysiological Recording in the Brain of Intact Adult Zebrafish

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Cited by 14 •

2013

This paper describes how an adult zebrafish can be immobilized, intubated, and used for in vivo electrophysiological experiments to allow recordings and manipulation of neural activity in an intact animal.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

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