Stereotactic Guidance
Stereotactic Guidance - Related Videos
04:50
Operative Technique and Nuances for the Stereoelectroencephalographic (SEEG) Methodology Utilizing a Robotic Stereotactic Guidance System
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Cited by 1 •
2023
The SEEG methodology is simplified and made faster with a stereotactic robot. Careful attention must be paid to the registration of the preoperative volumetric MRI to the patient prior to use of the robot in the OR. The robot streamlines the procedure, leading to decreased operative times and accurate implantations.
10:35
Stereotactic Radiosurgery for Gynecologic Cancer
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Cited by 14 •
2012
Stereotactic body radiotherapy (SBRT) involves image-guided, ablative radiation delivered to cancer targets refractory to chemotherapy or to conventional radiation treatment. The robotic-armed Cyberknife SBRT system, using sophisticated target localization, delivers hypofractionated radiation doses capable of sterilizing cancer targets. This article will consider new therapeutic roles of SBRT for gynecological cancers.
10:14
Automated Robotic Dispensing Technique for Surface Guidance and Bioprinting of Cells
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Cited by 9 •
2016
This protocol describes a bioprinting methodology using an automated robotic depositing system that incorporates etched topographical guidance cues with the precision deposition of a cell bearing hydrogel bioink. The printed cells are directly delivered to the etched features and are able to sense and orientate with them.
10:30
Use of pHluorin to Assess the Dynamics of Axon Guidance Receptors in Cell Culture and in the Chick Embryo
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Cited by 10 •
2014
We describe here the use of a pH-sensitive green fluorescent protein variant, pHluorin, to study the spatio-temporal dynamics of axon guidance receptors trafficking at the cell surface. The pHluorin-tagged receptor is expressed both in cell culture and in vivo, using electroporation of the chick embryo.
07:54
Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
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Cited by 15 •
2015
Stereotactic injection of lentiviruses expressing cDNAs or shRNAs can modulate gene expression in specific brain areas of mice. Here, we present a protocol to combine stereotactic injections with behavioral tasks, such as the Open Field Test (OFT) and the Forced Swim Test (FST).
FAQs
Imaging identifies the target and surrounding anatomy, while coordinates relate that location to anatomical landmarks and guide the planned trajectory. This translation from scan to instrument placement connects pre-procedure anatomical information with controlled action in the brain. The resulting plan can direct an electrode, biopsy needle, injection device, or other instrument toward a selected site while aiming to limit disruption to nearby tissue.
Rigid-frame guidance uses a fixed framework to establish the spatial reference for instrument placement. Frameless navigation uses a guidance system without that rigid frame while still translating imaging information into a controlled trajectory. Both approaches support precise targeting, but they represent different ways to maintain spatial guidance during procedures such as electrode placement, biopsy, or targeted injection.
Trajectory selection determines how an instrument approaches the intended target and therefore influences the amount of surrounding tissue encountered. Stereotactic planning uses the target location, anatomical landmarks, and medical imaging to establish a controlled path. This is particularly important for deep brain procedures, where accurate placement can improve measurement or treatment precision while limiting unnecessary disruption.
A typical workflow begins by identifying the target on medical images and relating it to anatomical landmarks. The team then selects a trajectory and establishes guidance with either a rigid frame or frameless navigation. Finally, the chosen instrument is advanced along the planned path toward the target. The same general workflow can support electrodes, biopsy needles, injection devices, or other instruments.
The guidance system can direct several instrument types, depending on the scientific or clinical objective. Examples include electrodes for deep brain stimulation or circuit studies, biopsy needles for sampling, and injection devices for targeted drug delivery. Because the method links imaging-defined targets with controlled placement, it can be adapted to different procedures without changing its central targeting principle.
In neuroscience, stereotactic guidance supports deep brain stimulation, neurosurgical biopsy, targeted drug delivery, and experimental investigations of brain circuits. These applications differ in what the instrument does after reaching the target, but all depend on accurate localization and placement. The approach can improve measurement accuracy in circuit studies and treatment precision when interventions must reach specific brain regions.